血清附睾蛋白4、糖类抗原125及19-9水平在老年卵巢癌诊断及病理类型鉴别中的临床价值

发布时间：2018-05-15 04:02

本文选题：卵巢癌 + 附睾蛋白　；参考：《中国老年学杂志》2015年12期

【摘要】：目的研究肿瘤标志物人附睾蛋白(HE)4、糖类抗原(CA)125、CA19-9在老年卵巢癌诊断及病理类型鉴别的临床应用价值。方法 100例老年卵巢癌设为恶性组,74例卵巢良性病变设为良性组,32例健康体检人员设为对照组,观察三组HE4、CA125及CA19-9平均血清水平及异常率,对其单独检测及并联检测进行方法学评价,并对不同病理类型卵巢癌血清HE4、CA125及CA19-9进行比较。结果恶性组HE4、CA125及CA19-9平均血清水平及异常率均与其他各组有统计学差异(P0.05),灵敏度以三种肿瘤标志物联合检测最高,达83.0%;特异度以HE4最高,达92.5%;约登指数与符合率均以三种肿瘤标志物联合检测最高;HE4、CA125在浆液性癌以及子宫内膜样癌升高较为显著,CA19-9在黏液性卵巢癌升高较为显著。结论 HE4、CA125及CA19-9的联合检测对卵巢癌的早期诊断具有重要的临床应用价值。
[Abstract]:Objective to study the clinical application value of tumor markers human epididymal protein (HEC) 4 and carbohydrate antigen CA125 (CA19-9) in the diagnosis and differential diagnosis of senile ovarian cancer. Methods one hundred cases of ovarian cancer were divided into malignant group (n = 74) and benign group (n = 32) as control group. The mean serum levels and abnormal rates of HE4CA125 and CA19-9 in three groups were observed. The methods of separate detection and parallel detection were evaluated, and the serum HE4 CA125 and CA19-9 were compared among different pathological types of ovarian cancer. Results the mean serum levels and abnormal rates of HE4, CA125 and CA19-9 in malignant group were significantly different from those in other groups (P 0.05). The sensitivity of the three tumor markers was the highest (83.0), and the specificity of HE4 was the highest. The Yorden index and coincidence rate were detected by three kinds of tumor markers in serous carcinoma and endometrial carcinoma. CA19-9 was significantly higher in mucinous ovarian cancer. Conclusion the combined detection of HE4 and CA125 and CA19-9 has important clinical value in early diagnosis of ovarian cancer.
【作者单位】：海南省农垦三亚医院检验科;海南省农垦三亚医院妇产科;
【基金】：海南省卫生厅课题(琼卫2012PT-09)
【分类号】：R737.31

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