动态增强MRI定量参数与高强度聚焦超声消融子宫肌瘤疗效的相关性研究

发布时间：2018-05-16 11:14

本文选题：动态增强磁共振成像 + 高强度聚焦超声消融　；参考：《重庆医科大学》2017年硕士论文

【摘要】：目的探讨动态增强MRI(DCE-MRI)定量参数与高强度聚焦超声(high-intensity focused ultrasound,HIFU)子宫肌瘤消融术疗效的相关性。方法HIFU术前对65例子宫肌瘤患者(82个子宫肌瘤)行DCE-MRI检查,经后处理软件获得子宫肌瘤定量参数Ktrans、Ve、Kep、Vp值以及子宫肌层定量参数Ktrans值,分析子宫肌瘤术前定量参数与其HIFU术后消融率的相关性。将子宫肌瘤按其Ktrans值高于(或低)相应子宫肌层分为高Ktrans肌瘤及低Ktrans肌瘤,比较两组肌瘤Ktrans以及消融率的差异。结果肌瘤消融率与肌瘤Ktrans值呈负相关(r=㧟0.411),具有统计学意义(P0.01)。肌瘤消融率与肌瘤Ve、Kep、Vp值的相关性无统计学意义(P0.05)。高Ktrans肌瘤与低Ktrans肌瘤间消融率及Ktrans值差异具有统计学意义(P均0.01),前者Ktrans值较后者高,而消融率较后者低。结论子宫肌瘤Ktrans值越高,其HIFU消融效果越差。对照相应子宫肌层Ktrans值能够初步判断子宫肌瘤的消融效果。DCE-MRI可为子宫肌瘤HUFI消融术选择患者提供依据。
[Abstract]:Objective to investigate the correlation between dynamic enhanced focused DCE-MRI quantitative parameters and the effect of high-intensity focused ultrasound (HIFU) hysteromyoma ablation. Methods Sixty-five patients with uterine leiomyoma (82 uterine leiomyomas) were examined by DCE-MRI before HIFU. The quantitative parameters of uterine leiomyoma were obtained by post-processing software, including KTrans-Veg KepVp and Ktrans of uterine myometrium. To analyze the correlation between preoperative quantitative parameters of uterine leiomyoma and ablation rate after HIFU. Uterine leiomyoma was divided into high Ktrans myoma and low Ktrans myoma according to its Ktrans value higher (or lower). The difference of Ktrans and ablation rate between the two groups was compared. Results there was a negative correlation between the ablation rate and the Ktrans value of leiomyoma (P 0.01). There was no significant correlation between the ablation rate of leiomyoma and the value of V _ p in leiomyoma (P 0.05). There were significant differences in ablation rate and Ktrans value between high Ktrans myoma and low Ktrans myoma (P < 0.01). The Ktrans value of the former was higher than that of the latter, and the ablation rate was lower than that of the latter. Conclusion the higher the Ktrans value of uterine leiomyoma, the worse the effect of HIFU ablation. Compared with the corresponding myometrium Ktrans value, DCE-MRI can preliminarily judge the ablation effect of uterine leiomyoma. DCE-MRI can provide evidence for the choice of uterine myoma HUFI ablation.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.33;R445.2

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