承德地区HPV感染及危险因素分析

发布时间：2018-05-16 19:46

  本文选题：人乳头瘤病毒(HPV) + 宫颈病变　； 参考：《中国公共卫生》2016年12期

【摘要】：目的了解河北省承德市女性宫颈人乳头瘤病毒(HPV)感染情况,分析HPV感染的危险因素,为HPV感染及宫颈癌防治提供理论依据。方法于2013年1月—2016年1月在承德市8县3区选取4 250名女性进行问卷调查、液基薄层细胞学检查(TCT)及宫颈HPV DNA检测,对HPV16/18型和细胞学提示不能明确意义的非典型鳞状上皮细胞(ASCUS)、非典型腺上皮细胞(AGC)及以上患者进行阴道镜检查、组织活检及病理检查,分析不同宫颈病变及年龄组HPV感染情况,采用多因素logistic回归模型分析HPV感染危险因素。结果承德地区4 250名妇女HPV感染819例,感染率为19.27%,最常见的5种HPV高危型别依次为16、58、52、39、51型。伴随宫颈上皮内瘤变(CIN)级别升高,HPV感染率升高,宫颈癌HPV感染率为100%。20岁组HPV感染率最高,为21.74%;30~49岁及≥60岁组为HPV感染高峰。吸烟、首次性生活年龄过早、受教育程度低(高中以下)、接触性出血和宫颈柱状上皮异位为HPV感染的危险因素,避孕套避孕和了解宫颈癌及HPV为HPV感染的保护因素。结论HPV感染与CIN及宫颈癌密切相关,加强对具有HPV感染危险因素人群的筛查及管理可有效预防宫颈癌的发生。
[Abstract]:Objective to investigate the infection of cervical human papillomavirus (HPV) in women in Chengde, Hebei Province, and to analyze the risk factors of HPV infection, and to provide theoretical basis for the prevention and treatment of HPV infection. Methods from January 2013 to January 2016, 4 250 women were selected from 8 counties and 3 districts in Chengde City to carry out questionnaire survey, liquid based thin layer cytology examination (TCTT) and cervical HPV DNA detection. The patients with atypical squamous epithelial cells (ASSCS) or atypical glandular epithelial cells (AGC) or above whose HPV16/18 and cytology were not clear were examined by colposcopy, biopsy and pathological examination. The infection of HPV in different cervical lesions and age groups was analyzed. Multivariate logistic regression model was used to analyze the risk factors of HPV infection. Results there were 819 cases of HPV infection among 4 250 women in Chengde area, the infection rate was 19.27%. The most common high risk type of HPV was 1658A52P39C51. With the increase of the grade of cervical intraepithelial neoplasia (cin), the infection rate of HPV was increased. The infection rate of HPV was the highest in the group of 100. 20 years old, and the highest in the group of 30 ~ 49 years of age and 鈮，

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