2012-2015年妇科患者感染人乳头瘤病毒型别及相关因素分析

发布时间：2018-05-18 10:12

  本文选题：人乳头瘤病毒 + 型别检测　； 参考：《中国病原生物学杂志》2017年01期

【摘要】：目的了解妇产科就诊患者感染人乳头瘤病毒(HPV)型别分布情况,并分析感染发生相关因素,为临床抗感染治疗提供指导。方法选取2012-2015年医院妇产科就诊的患者5 198例,筛查患者感染HPV分型。采集患者标本提取DNA,使用HPV核酸扩增分型检测试剂盒检测分型情况,采取问卷调查方式统计受试者年龄、流产次数、性伴侣数、吸烟史及避孕方式等,对感染发生相关因素进行分析。结果 2012-2015年收集的5 198例患者中,HPV感染1 030例,感染率为19.82%;各年度HPV感染率分别为23.20%、21.84%、19.97%和18.48%。HPV单型感染菌株333株,单型检出率为6.41%;HPV多型感染菌株867株,多型检出率为16.68%。2012-2015年患者HPV感染型别分别为HPV16、HPV52、HPV58、HPV18、HPV33、HPV11、HPV56、HPV68、HPV31、HPV51、HPV59、HPV35和HPV39型,各型别检出率分别为18.25%、15.92%、11.08%、8.92%、8.08%、6.92%、6.08%、5.75%、5.08%、5.08%、3.92%、2.83%和2.08%。相关因素分析发现,患者年龄和避孕方式不是影响HPV感染的相关因素;流产≥3次、性伴侣数≥2个以及有吸烟史是HPV感染的危险因素(χ2=112.9122、350.4139、347.1738,P均0.01)。结论 2012-2015年妇科患者染HPV感染率呈下降趋势,主要感染型别为HPV16、HPV52和HPV58型;且性伴侣数、流产次数以及吸烟史是影响HPV感染发生的相关因素。
[Abstract]:Objective to investigate the distribution of HPV-infected patients in obstetrics and gynecology, and to analyze the related factors of infection in order to provide guidance for clinical anti-infection therapy. Methods 5 198 patients with gynecology and obstetrics in our hospital from 2012 to 2015 were selected to screen for HPV typing. HPV nucleic acid amplification assay kit was used to detect the type of patients. The age of subjects, the number of miscarriages, the number of sexual partners, the history of smoking and the methods of contraception were counted by questionnaire survey. The related factors of infection were analyzed. Results among the 5 198 patients collected from 2012 to 2015, 1 030 cases (19.82%) were infected with HPV, and the infection rate of HPV in each year was 23. 20%, 19. 84% and 333 strains of 18.48%.HPV monotype, respectively, and the detection rate of single type was 6. 41% and 867 strains respectively. The detection rate of polytype was 16.68.The number of HPV infection types in patients with HPV16 / HPV52 / HPV58 / HPV38 / HPV56 / HPV56 / HPV51 / HPV51 / HPV51 / HPV59 / HPV35 and HPV39 was 18.255.92.02 / 11.088.92/ 8.086.086.086.085.755.755.085.083.92HPV35 and HPV39, respectively. The detectable rates of each type were 18.25515.92n11.088.928.086.92m and 6.085.755.755.085.085.085.083.92% and 2.08%, respectively. The risk factors of HPV infection were age and contraceptive method (蠂 ~ 2 = 112.9122350.4139 / 347.1738), abortion 鈮，

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