HIV阳性孕妇所生子女低出生体重发生率及影响因素分析

发布时间：2018-05-19 03:01

本文选题：艾滋病病毒 + 孕妇　；参考：《中国艾滋病性病》2017年11期

【摘要】：目的探讨感染艾滋病病毒(HIV)的孕妇所生子女低出生体重情况及其相关影响因素,为中国HIV母婴阻断工作提供参考。方法以2003年1月至2014年12月湖北、河北、山西部分县市及新疆伊宁市发现的HIV阳性孕妇及其子女为研究对象,收集相关资料进行卡方检验及Logistic回归分析,探讨其子女低出生体重的危险因素。结果纳入研究的608名子女中,低出生体重31人(5.10%)。多因素Logistic回归分析表明,子女低出生体重的危险因素包括:阻断方案中含有蛋白酶抑制剂(PI)[比值比(OR)=4.491,95%可信区间(CI):1.336~15.093]、子女HIV阳性(OR=4.652,95%CI:1.547~13.995)。结论应尽早发现HIV阳性孕妇并进行抗反转录病毒治疗,同时应警惕PI类药物对子女出生体重的影响,做好早期预防和管理,以降低低出生体重发生率。
[Abstract]:Objective to investigate the low birth weight (LBW) of pregnant women infected with HIV / AIDS (HIV / AIDS) and its related factors, and to provide a reference for the blocking of HIV mother and child in China. Methods from January 2003 to December 2014, pregnant women and their children with HIV positive were collected for chi-square test and Logistic regression analysis. To explore the risk factors of low birth weight for their children. Results among the 608 children in the study, 31 children with low birth weight were 5.10. Multivariate Logistic regression analysis showed that the risk factors for low birth weight of children were as follows: the blocking regimen contained protease inhibitor Pi) [the ratio was 4.491% 95% confidence interval (CI: 1.336) 15.093], and the HIV positive rate of children was 1.652% 95% CI: 1.547% 13.995. Conclusion HIV positive pregnant women should be detected as soon as possible and treated with antiretrovirus, and the influence of Pi drugs on the birth weight of their children should be warned, and early prevention and management should be done in order to reduce the incidence of low birth weight.
【作者单位】：武汉大学中南医院;昆明医科大学;新疆维吾尔自治区伊宁市妇幼保健院;湖北省南漳县妇幼保健院;湖北省武汉市武昌区疾病预防控制中心;湖北省麻城市疾病预防控制中心;湖北省崇阳县疾病预防控制中心;湖北省大冶市疾病预防控制中心;
【基金】：国家自然科学基金(81000758) 中国性病艾滋病防治协会·艾伯维妇幼关爱及预防母婴传播基金(PMTCT 2017-005) 武汉中青年医学骨干人才项目~~
【分类号】：R714.251

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