子宫内膜异位症患者术后应用左炔诺孕酮宫内缓释系统效果观察

发布时间：2018-05-19 19:52

本文选题：子宫内膜异位症 + 左炔诺孕酮宫内缓释系统　；参考：《山东医药》2015年16期

【摘要】：目的观察子宫内膜异位症(EMs)患者术后应用左炔诺孕酮宫内缓释系统(LNG-IUS)的临床效果。方法将82例经手术治疗的EMs患者随机分为观察组和对照组各41例,观察组给予LNG-IUS治疗,对照组口服孕三烯酮。治疗6个月后观察疗效,并检测两组血清超敏C反应蛋白(hs-CRP)和血管内皮生长因子(VEGF)。结果观察组显效20例、有效19例、无效2例、总有效率95.1%,对照组分别为12、21、8例和80.5%;两组总有效率比较,P0.05。观察组复发1例,对照组复发6例,P0.05。与治疗前比较,两组治疗后血清hs-CRP、VEGF均降低,观察组降低更明显,P均0.05。结论 LNG-IUS可降低EMs术后患者血清hs-CRP和VEGF水平,并有助于改善病情、降低复发率。
[Abstract]:Objective to observe the clinical effect of levonorgestrel intrauterine sustained release system (LNG-IUS) in patients with endometriosis. Methods Eighty-two patients with EMs were randomly divided into two groups: the observation group (n = 41) and the control group (n = 41). The observation group was treated with LNG-IUS and the control group was treated by oral administration of pregnenone. After 6 months of treatment, the therapeutic effect was observed, and the serum hypersensitive C-reactive protein hs-CRP and vascular endothelial growth factor (VEGF) were detected in both groups. Results in the observation group, there were 20 cases with remarkable effect, 19 cases with effective effect, and 2 cases with no effect. The total effective rate was 95.1in the control group, 8 cases in the control group and 80.5% in the control group, and the total effective rate in the two groups was higher than that in the control group (P 0.05). One case recurred in the observation group and 6 cases in the control group (P 0.05). Compared with before treatment, serum hs-CRP VEGF decreased after treatment in both groups, and the decrease was more obvious in observation group (P < 0.05). Conclusion LNG-IUS can decrease the levels of serum hs-CRP and VEGF after EMs, and can improve the condition and reduce the recurrence rate.
【作者单位】：肥城市人民医院;
【分类号】：R711.71

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