雌、孕激素受体及细胞色素芳香化酶在绝经前妇女子宫内膜息肉中的表达及意义

发布时间：2018-05-20 02:18

本文选题：子宫内膜息肉 + 雌激素受体　；参考：《广东医学》2015年19期

【摘要】：目的观察绝经前妇女子宫内膜息肉腺上皮与间质中雌激素受体(ER)和孕激素受体(PR)、细胞色素芳香化酶P450(P450arom)的表达,探讨绝经前子宫内膜息肉的发生机制。方法选择不孕不育患者86例,其中经病理证实为增殖期子宫内膜的患者33例作为对照组,经病理证实为子宫内膜息肉的患者53例作为息肉组。在月经期收集两组患者血清,采用化学发光法测定基础性激素。于子宫内膜增殖期在宫腔镜下收集两组患者的子宫内膜或息肉,采用免疫组化方法测定腺上皮与间质中ER、PR、P450arom的表达。结果两组患者雌二醇、孕酮、卵泡刺激素、黄体生成素、睾酮水平比较,差异无统计学意义(P0.05)。ER在对照组与息肉组患者腺上皮中的表达差异无统计学意义(P=0.313),ER在对照组与息肉组患者间质中的表达差异无统计学意义(P0.05)。PR在息肉组患者腺上皮和间质中的表达均低于对照组患者(P0.05)。与子宫内膜息肉周围正常内膜相比,P450arom在子宫内膜息肉中的表达较强(P0.05),P450arom在子宫内膜息肉周围正常内膜中相对呈低水平表达,且其表达水平不随月经周期而改变,增生期和分泌期差异无统计学意义(P0.05)。P450arom与ER、PR在绝经前妇女子宫内膜息肉中的表达无显著相关性(r=0.124、0.247,P0.05)。结论 PR在腺上皮及间质中的低表达可能与绝经前子宫内膜息肉的形成密切相关,是导致不孕症的重要因素。而ER与PR、P450arom在月经的增殖期局部子宫内膜表达的失衡是不孕症子宫内膜息肉形成的原因。
[Abstract]:Objective to investigate the expression of estrogen receptor (ERR), progesterone receptor (PRN) and cytochrome aromatase (P450 P450 aromin) in the glandular epithelium and stroma of endometrial polyps in premenopausal women, and to explore the mechanism of premenopausal endometrial polyps. Methods A total of 86 infertile women with infertility were selected. 33 patients with proliferative endometrium were selected as control group and 53 patients with endometrial polyps confirmed by pathology as polyps group. Serum samples of two groups of patients were collected during menstrual period, and basic sex hormones were determined by chemiluminescence. The endometrial or polyps of the two groups were collected under hysteroscopy during endometrial proliferation. The expression of ERP P450 arom in glandular epithelium and stroma was determined by immunohistochemical method. Results the levels of estradiol, progesterone, follicle stimulating hormone, luteinizing hormone and testosterone were compared between the two groups. There was no significant difference in the expression of P0.05P. ER in the glandular epithelium of the control group and the polyp group. There was no significant difference in the expression of P0. 313. ER in the stroma of the control group and the polyp group. There was no significant difference in the expression of P0. 05. PR in the glandular epithelium of the polyp group. The expression of P0. 05 in the interstitial tissue was lower than that in the control group. Compared with the normal endometrium around the endometrial polyps, the expression of P450arom in the endometrial polyps was stronger than that in the normal endometrium around the endometrial polyps. The expression of P450 arom was relatively low in the normal endometrium around the endometrial polyps, and its expression level did not change with the menstrual cycle. There was no significant difference between proliferative phase and secretory phase. There was no significant correlation between P0.05A. P450arom and ERP PR expression in premenopausal women with endometrial polyps. Conclusion the low expression of PR in glandular epithelium and stroma may be closely related to the formation of premenopausal endometrial polyps and may be an important factor leading to infertility. The imbalance of ER and PRP450 arom expression in endometrium during menstrual proliferation is the cause of endometrial polyps in infertility.
【作者单位】：河南大学淮河医院妇产科;
【分类号】：R711.74

【参考文献】