妊娠合并系统性红斑狼疮42例临床分析

发布时间：2018-05-22 14:31

  本文选题：妊娠 + 系统性红斑狼疮　； 参考：《实用妇产科杂志》2015年04期

【摘要】：目的:探讨妊娠合并系统性红斑狼疮(SLE)患者孕期病情活动与否对母婴结局的影响。方法:回顾性分析2007年1月至2013年12月北京大学第三医院收治的42例妊娠合并SLE患者的临床资料,SLE病情活动组23例,非活动组19例。结果:1除外流产,SLE病情活动组终止妊娠的孕周较非活动组小(36.2±2.8周vs 38.1±0.7周,P=0.021),早产率较非活动组高(46.7%vs 6.7%,P=0.035),活产儿平均体重低于非活动组(2456.2±754.6 g vs 2956.3±420.0 g,P=0.048)。2各类合并症中,妊娠合并狼疮肾炎发生率最高(19.0%),妊娠期高血压疾病在SLE病情活动组发生率明显高于非活动组(34.8%vs 5.3%,P=0.027),其他如妊娠期糖尿病、胎儿生长受限、羊水少、胎膜早破、前置胎盘等并发症两组间比较差异均无统计学意义(P0.05)。3孕前每天激素用量10 mg组流产及早产发生率明显高于每天激素用量≤10 mg组(55.6%vs 9.5%,75.0%vs 5.3%,P均0.05)。结论:SLE患者妊娠时发生妊娠期高血压疾病、早产、低出生体重儿的几率在SLE病情活动时明显增加,建议在病情稳定半年以上或疾病缓解期受孕,控制孕前激素用量。孕前激素用量10mg的患者流产及早产率高。
[Abstract]:Objective: to investigate the effect of maternal and infant outcome in pregnancy with systemic lupus erythematosus (SLE). Methods: the clinical data of 42 pregnant women with SLE were retrospectively analyzed from January 2007 to December 2013 in the third Hospital of Peking University. 23 cases in active group and 19 cases in inactive group. Results the gestational weeks of termination of pregnancy in active group were 36.2 卤2.8 weeks vs 38.1 卤0.7 weeks, and the preterm delivery rate was 46.7% vs 6.7%. The average body weight of live infants was lower than that of inactive group (2456.2 卤754.6 g vs 2956.3 卤420.0 g P0. 048). The incidence of pregnancy with lupus nephritis was the highest (19.0%). The incidence of hypertensive disorder complicating pregnancy in the active group of SLE was significantly higher than that in the inactive group (34.8 vs 5.3%). Other factors such as gestational diabetes mellitus, fetal growth restriction, oligohydramnios and premature rupture of fetal membrane were observed. There was no significant difference between the two groups in the incidence of abortion and premature delivery before pregnancy. The incidence of abortion and premature delivery was significantly higher in the group of 10 mg / day hormone dosage than in the group of 鈮，

本文编号：1922469