新疆汉族和少数民族子宫内膜异位症患者血清和腹腔液VEGF、TNF-α和IL-6的表达及相关因素分析

发布时间：2018-05-23 10:58

本文选题：子宫内膜异位症 + 血管内皮生长因子　；参考：《中国现代医学杂志》2015年09期

【摘要】：目的研究新疆汉族和少数民族子宫内膜异位症(EMs)患者血清和腹腔液中VEGF、TNF-α和IL-6的水平差异,探讨发生子宫内膜异位和民族之间、细胞因子的关联因素,为新疆汉族与少数民族子宫内膜异位症患者的诊断及治疗提供参考资料。方法随机抽取汉族和少数民族内异症患者80例,采用酶联免疫分析法测定患者血清和腹腔液中VEGF、TNF-α和IL-6的含量。结果少数民族TNF-α和IL-6在血清和腹腔液中的含量低于汉族,差异有统计学意义(P0.05);少数民族组血清和腹腔液中VEGF的含量与汉族组比较差异无统计学意义(P0.05)。多因素分析显示,血清TNF-α的含量、民族、以及民族与血清TNF-α含量之间的交互作用是影响内异症发生的主要因素。结论汉族和少数民族EMs患者血液及腹腔液中TNF-α和IL-6水平有差异性,对新疆不同民族EMs患者的治疗可能提供了一个新的提示,但尚需扩大样本进一步证实。
[Abstract]:Objective to study the levels of VEGF TNF- 伪 and IL-6 in serum and peritoneal fluid of patients with endometriosis of Han and minority nationalities in Xinjiang, and to explore the correlation factors of cytokines between endometriosis and nationality. To provide reference for diagnosis and treatment of endometriosis in Han and minority nationalities in Xinjiang. Methods Enzyme-linked immunosorbent assay (Elisa) was used to determine the levels of VEGF TNF- 伪 and IL-6 in serum and peritoneal fluid of 80 Han and ethnic minority patients with endometriosis. Results the contents of TNF- 伪 and IL-6 in serum and peritoneal fluid of minority nationality were lower than those in Han nationality, the difference was statistically significant (P 0.05), but the content of VEGF in serum and celiac fluid of minority group was not significantly different from that of Han nationality group (P 0.05). Multivariate analysis showed that the content of serum TNF- 伪, ethnic group, and the interaction between nationality and serum TNF- 伪 were the main factors affecting the occurrence of endometriosis. Conclusion there are differences in the levels of TNF- 伪 and IL-6 in blood and peritoneal fluid between Han and minority EMs patients, which may provide a new indication for the treatment of EMs patients of different nationalities in Xinjiang, but need to be further confirmed by expanding the sample.
【作者单位】：新疆医科大学第一临床医学院;新疆医科大学第一附属医院妇产科;
【分类号】：R711.71

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