不同妊娠期孕妇人乳头瘤病毒感染情况及对母婴结局的影响

发布时间：2018-05-24 18:08

本文选题：妊娠期 + 人乳头瘤病毒　；参考：《中华医院感染学杂志》2017年15期

【摘要】：目的探讨不同妊娠期孕妇人乳头瘤病毒(HPV)感染情况及其对母婴结局的影响。方法选择医院2014年1月-2015年12月孕期进行HPV筛查的早孕期女性96例作为早孕组、中孕期女性96例作为中孕组、晚孕期女性96例为晚孕组,根据HPV是否阳性分为HPV感染组(HPV阳性组)108例和对照组(HPV阴性组)180例;测定孕妇宫颈分泌物和新生儿口咽部分泌物HPV感染情况。结果 HPV感染108例,以高危型HPV感染为主,共61例占56.5%;早孕组感染18例,感染率为18.8%,中孕组感染33例,感染率为34.4%,晚孕组感染57例,感染率为59.4%,3组比较差异有统计学意义(P0.05);不同分娩方式新生儿HPV感染阳性率比较,差异无统计学意义。结论随着妊娠孕周的增加宫颈HPV感染率升高,宫颈HPV感染可垂直传播给胎儿,剖宫产不能降低新生儿HPV感染率。
[Abstract]:Objective to investigate the infection of human papillomavirus (HPV) in pregnant women with different gestational stages and its effect on maternal and infant outcomes. Methods from January 2014 to December 2015, 96 women with HPV screening were selected as the early pregnancy group, 96 women in the second trimester as the secondary pregnancy group, and 96 women in the late pregnancy as the late pregnancy group. According to whether HPV was positive or not, 108 cases in HPV infection group and 180 cases in control group were divided into HPV positive group and control group, and HPV infection in cervical secretion of pregnant women and oropharyngeal secretion of newborn were measured. Results there were 108 cases of HPV infection, 61 cases were high risk type HPV infection, 18 cases were infection in early pregnancy group, 33 cases were infection in middle pregnancy group, 57 cases were infection in late pregnancy group, 33 cases in middle pregnancy group, 57 cases in late pregnancy group, 33 cases in middle pregnancy group, 34 4 cases in middle pregnancy group and 57 cases in late pregnancy group. The infection rate was 59.4% and there was no significant difference among the three groups. There was no significant difference in the positive rate of HPV infection among the newborns with different delivery modes. Conclusion with the increase of HPV infection rate in the cervix during gestational week, cervical HPV infection can be transmitted vertically to the fetus, and cesarean section can not reduce the infection rate of neonatal HPV.
【作者单位】：中国人民解放军第一一三医院检验科;中国人民解放军第一一三医院妇产科;
【基金】：浙江省医药卫生一般研究基金资助项目(2015KYB349)
【分类号】：R714.25

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