子宫内膜腺癌组织FRA和CA125的表达及意义

发布时间：2018-05-25 22:14

本文选题：子宫内膜肿瘤 + 子宫内膜增生症　；参考：《实用医学杂志》2017年04期

【摘要】：目的:探讨叶酸受体α(FRA)与CA125在子宫内膜癌的发生发展中的作用及临床意义。方法:收集60例子宫内膜腺癌、46例子宫内膜增生症及10例正常子宫内膜组织病理标本,采用免疫组化法检测各组内膜组织中FRA、CA125的表达情况,比较其差异及与临床病理特征的关系。结果:子宫内膜癌组织中FRA阳性率为93.3%,高表达率为65.0%,明显高于子宫内膜增生症组和正常组(P0.05);在内膜癌组织中,FRA的高表达与年龄、FIGO分期、分化程度相关(P0.05),与肌层浸润深度等方面的差异无统计学意义(P0.05)。子宫内膜增生症中伴不典型增生者的FRA表达较其他增生亚型高。CA125在内膜癌及内膜增生症中的高表达率均明显高于对照组(正常组)(P0.05)。结论:FRA可能参与到子宫内膜癌的发生发展过程中,且对子宫内膜癌的预后评估有一定的指导意义,并有望成为子宫内膜癌的治疗靶点。CA125的表达在子宫内膜病变过程中起一定作用。FRA及CA125两者之间的关系仍有待更深入的研究及探讨。
[Abstract]:Objective: to investigate the role and clinical significance of folate receptor 伪 FRAand CA125 in the development of endometrial carcinoma. Methods: the expression of FRACA125 in 60 cases of endometrial adenocarcinoma and 46 cases of endometrial hyperplasia and 10 cases of normal endometrial tissue were detected by immunohistochemistry. To compare its difference and its relationship with clinicopathological features. Results: the positive rate of FRA in endometrial carcinoma was 93. 3 and the high expression rate was 65. 0, which was significantly higher than that in endometrial hyperplasia and normal group (P0. 05). The degree of differentiation was related to P0.05, but there was no significant difference between P0.05 and the depth of myometrial infiltration. The expression of FRA in endometrial hyperplasia with atypical hyperplasia was significantly higher than that in other hyperplasia subtypes. CA125 expression in endometrial carcinoma and endometrial hyperplasia was significantly higher than that in control group (P 0.05). Conclusion: FRA may be involved in the development of endometrial carcinoma, and may be helpful to the prognosis evaluation of endometrial carcinoma. The expression of CA125 in endometrial carcinoma is expected to play a role in the process of endometrial lesions. The relationship between FRA and CA125 remains to be further studied and discussed.
【作者单位】：南方医科大学;佛山市第一人民医院妇产科;南方医科大学附属小榄医院病理科;咸宁市中心医院妇产科;南方医科大学附属小榄医院妇产科;
【基金】：广东省科技计划(编号:2013B021800113) 中山市科技计划(编号:2014A1FC020)
【分类号】：R737.33

【相似文献】