卵巢早衰及卵巢功能减退患者血清IL-21的水平变化

发布时间：2018-05-26 11:19

本文选题：IL- + 卵巢储备功能　；参考：《免疫学杂志》2015年05期

【摘要】：目的探讨人外周血白细胞介素21(interleukin-21,IL-21)与卵巢早衰(premature ovarian failure,POF)及卵巢功能减退(decreased ovarian reserve,DOR)的发病是否相关。方法收集POF患者25例、DOR患者14例以及健康体检的育龄女性18例作为对照,采用放射免疫法检测血清IL-21水平,并与其他实验室指标进行相关性分析。结果 POF组和DOR组患者的血清IL-21水平较对照组明显升高,差异有统计学意义(F=4.971,P=0.010),POF组和DOR组患者的血清IL-21水平近似,差异无统计学意义(P0.05)。IL-21分别与促卵泡激素(follicle stimulating hormone,FSH)、抗苗勒管激素(anti-miillerian hormone,AMH)呈正相关(r=0.389,P=0.003;r=0.275,P=0.040),IL-21分别与雌二醇(estradiol,E2)、平均卵巢体积(mena ovarian volume,MOV)呈负相关(r=-0.377,P=0.004;r=-0.271,P=0.042)。结论血清IL-21在POF患者中升高,而且在DOR患者中明显升高,并与卵巢储备功能相关,提示IL-21可能参与早期POF的发病过程,可望成为防治POF的新途径。
[Abstract]:Objective to investigate the relationship between interleukin-21 (IL-21) in human peripheral blood and premature ovarian failure (POF) in premature ovarian failure (POF) and ovarian dysfunction ovarian reserve (DORDORA). Methods Serum IL-21 levels were measured by radioimmunoassay (RIA) in 25 POF patients (n = 14) and 18 healthy women (n = 18). Results the level of serum IL-21 in POF group and DOR group was significantly higher than that in control group, and the difference was statistically significant. The serum IL-21 level of patients in POF group and DOR group was similar to that in DOR group. There was no significant difference between IL-21 and follicle stimulating hormone follicle stimulating hormoid FSHH, anti-miillerian hormone anti-miillerian moneymov, respectively. There was a negative correlation between IL-21 and estradiol estradiolus E2V. The mean ovarian volume was negatively correlated with that of estradiol ovarian volume mov. Conclusion Serum IL-21 is higher in POF patients than in DOR patients, and is related to ovarian reserve function, suggesting that IL-21 may be involved in the pathogenesis of early POF and may be a new way to prevent and treat POF.
【作者单位】：南方医科大学珠江医院妇产科;
【基金】：广州市科技计划项目(11C32120702) 广东省科技计划项目(2012B031800123) 广东高校优秀青年创新人才培养计划项目育苗工程(2012LYM_0034)
【分类号】：R711.75

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