拟行辅助生殖技术夫妇染色体核型分析

发布时间：2018-05-27 01:27

本文选题：染色体异常 + 多态性　；参考：《现代妇产科进展》2017年03期

【摘要】：目的:分析拟行辅助生殖技术夫妇的染色体核型异常情况并探讨行染色体检查的必要性,为此类患者遗传咨询及辅助生殖技术的选择提供依据。方法:收集天津医科大学总医院近15年拟行IVF/ICSI-ET并行染色体核型分析的2621例患者,其中男性患者1365例,女性患者1256例。女性患者中无流产史573例,1次流产史446例,≥2次流产史237例。采用染色体G显带技术进行核型分析。结果:2621例患者中发现染色体异常71例,异常率为2.71%,其中男性35例(2.56%),女性36例(2.87%),染色体多态性率为4.85%。女性患者中有流产史组的染色体异常率与无流产史组比较,差异无统计学意义。结论:拟行辅助生殖技术人群中染色体异常率较高,建议行辅助生殖技术前常规行染色体检查。
[Abstract]:Objective: to analyze the abnormal karyotype of couples with assisted reproductive technology and to explore the necessity of chromosome examination in order to provide evidence for genetic counseling and selection of assisted reproductive technology in such patients. Methods: 2621 patients with IVF/ICSI-ET and chromosome karyotype analysis were collected from Tianjin Medical University General Hospital in recent 15 years, including 1365 male patients and 1256 female patients. Of the 573 female patients with no history of abortion, 446 had a history of one abortion, and 237 had a history of more than two abortions. Chromosome G banding technique was used for karyotype analysis. Results among the 2621 cases, 71 cases were found to have chromosomal abnormalities, and the abnormal rate was 2.71. Among them, 35 cases were male and 2.56%, 36 cases were female, and the rate of chromosome polymorphism was 4.85%. There was no significant difference in chromosome abnormality rate between women with history of abortion and those with no history of abortion. Conclusion: the rate of chromosomal abnormality in the population with assisted reproductive technology is high. It is suggested that chromosome examination should be performed before assisted reproductive technique.
【作者单位】：天津医科大学;天津医科大学总医院;
【分类号】：R714.8

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