老年卵巢癌患者远期疗效的相关影响因素

发布时间：2018-05-28 02:45

本文选题：卵巢癌 + 远期疗效　；参考：《中国老年学杂志》2015年22期

【摘要】：目的探讨影响老年卵巢癌患者远期疗效的相关因素。方法选取2009年1月至2012年6月152例老年卵巢癌患者,在初次治疗结束后对所有患者进行随访。根据远期疗效将上述患者分为观察组(45例)与对照组(107例),观察组在随访期内发生复发或转移,对照组在随访期内未发生复发、转移。结果单因素分析显示两组患者年龄、体质量指数、化疗方案、化疗周期数、激素替代治疗史、吸烟史相比无统计学差异(P0.05);两组患者肿瘤分期、病理类型、组织分级、术中淋巴结清扫、腹水细胞学阳性、肉眼可见残瘤、妇科肿瘤家族史相比有统计学差异(P0.05)。非条件Logistic回归分析结果显示肿瘤分期(OR=4.628 3,95%CI 2.375 5~9.017 69)、组织分级(OR=4.014 9,95%CI1.824 8~8.833 1)、腹水细胞学阳性(OR=3.322 4,95%CI=1.486 0~7.428 2)、肉眼可见残瘤(OR=3.482 7,95%CI=1.473 1~8.233 7)是影响老年卵巢癌患者远期疗效的独立危险因素(P0.05),术中淋巴结清扫(OR=0.237 0,95%CI=0.108 6~0.517 6)则是独立保护因素(P0.05)。结论多种因素可以影响老年卵巢癌患者的远期疗效,针对性地采取干预措施可以降低老年卵巢癌患者的复发率、转移率。
[Abstract]:Objective to investigate the related factors influencing the long-term outcome of elderly ovarian cancer patients. Methods 152 elderly patients with ovarian cancer from January 2009 to June 2012 were followed up at the end of initial treatment. According to the long-term effect, the patients were divided into observation group (n = 45) and control group (n = 107). Recurrence or metastasis occurred in the observation group during the follow-up period, but no recurrence or metastasis occurred in the control group during the follow-up period. Results the univariate analysis showed that there were no significant differences in age, body mass index, chemotherapy regimen, number of chemotherapy cycles, history of hormone replacement therapy and smoking history between the two groups (P 0.05). Intraoperative lymph node dissection, ascites cytology positive, naked eye residual tumor, gynecological tumor family history compared with the statistical difference (P 0.05). The results of non conditional Logistic regression analysis showed that the tumor stage was 4.628 3 + 95 CI 2.375 5 / 9.017 69, the tissue grade was 4.014 9 / 95 CI 1.824 8 / 8.833 1, the ascites cytology positive OR3.322 495% ~ 1.486 07.428 2, the naked eye showed residual tumor OR3.482 7 / 95CI 1.473 1 / 8.2337) was an independent risk factor affecting the long-term curative effect of the elderly patients with ovarian cancer. P0. 05 and 0. 237 0 ~ 95% CI 0.108 6 ~ 0. 517 6) were independent protective factors (P 0. 05). Conclusion many factors can affect the long-term curative effect of the elderly patients with ovarian cancer. Intervention can reduce the recurrence rate and metastasis rate of the elderly ovarian cancer patients.
【作者单位】：宁波市北仑区人民医院妇科;
【分类号】：R737.31

【参考文献】