子宫内膜样腺癌组织中eIF-4A与Cyclin D1的表达及其临床意义

发布时间：2018-05-29 21:23

本文选题：子宫内膜样腺癌 + 真核起始因子-4A　；参考：《青岛大学》2014年硕士论文

【摘要】：目的检测子宫内膜样腺癌组织中真核起始因子-4A (eIF-4A)、细胞周期蛋白D1(Cyclin D1)的表达,探讨其临床意义。方法通过免疫组织化学方法检测120例子宫内膜样腺癌组织及40例正常子宫内膜组织中eIF-4A及Cyclin D1蛋白的表达,并分析两者之间的相关性。结果eIF-4A蛋白在子宫内膜样腺癌组织中的阳性表达率(76.7%)明显高于其在正常子宫内膜组织中的阳性表达率(20.0%),差异有显著性(x2=38.72,P0.01),eIF-4A蛋白在子宫内膜样腺癌组织中的表达与肿瘤的临床病理分期(x2=13.36,P0.05)、淋巴转移(x2=4.36,P0.05)、组织分化程度(x2=12.32,P0.05)呈明显的相关性。Cyclin D1在子宫内膜样腺癌组织中的阳性表达明显高于其在正常子宫内膜组织中的阳性表达(x2=46.73, P0.05), Cyclin D1在子宫内膜样腺癌组织中的阳性表达与患者的组织分化程度(x2=24.73,P0.05)及淋巴结转移(x2=5.24,P0.05)密切相关。子宫内膜样腺癌组织eIF-4A与Cyclin D1的表达的呈显著的正相关(r=0.824,P0.01)。结论eIF-4A及Cyclin D1可能参与了子宫内膜样腺癌发生、进展及淋巴转移的过程,在子宫内膜样腺癌发生发展过程中eIF4A对Cyclin D1表达可能起调控作用,两者有望成为预测子宫内膜样腺癌恶性程度的重要生物学指标,有助于指导临床治疗方案的选择。
[Abstract]:Objective to detect the expression of eukaryotic initiation factor -4A eIF-4Am, cyclin D1(Cyclin D _ 1 in endometrial adenocarcinoma, and to explore its clinical significance. Methods the expression of eIF-4A and Cyclin D1 protein in 120 cases of endometrial adenocarcinoma and 40 cases of normal endometrium were detected by immunohistochemical method, and the correlation between them was analyzed. Results the positive expression rate of eIF-4A protein in endometrial adenocarcinoma tissues was significantly higher than that in normal endometrial tissues. The difference was significant in the expression and swelling of eIF-4A protein in endometrial adenocarcinoma tissues. The expression of Cyclin D1 in endometrial adenocarcinoma was significantly higher than that in normal endometrial tissue. The positive expression in endometrial adenocarcinoma was closely related to the degree of tissue differentiation (P 0.05) and lymph node metastasis (P 0.05). There was a significant positive correlation between the expression of eIF-4A and Cyclin D1 in endometrial adenocarcinoma. Conclusion eIF-4A and Cyclin D1 may be involved in the development, progression and lymphatic metastasis of endometrial adenocarcinoma. EIF4A may play a regulatory role in the expression of Cyclin D1 during the development of endometrioid adenocarcinoma. Both of them are expected to be an important biological index to predict the malignant degree of endometrial adenocarcinoma and to guide the choice of clinical treatment.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.33

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