血清CA125预测卵巢上皮癌治疗后复发的Meta分析

发布时间：2018-05-30 21:00

本文选题：CA + 卵巢上皮癌　；参考：《现代妇产科进展》2017年02期

【摘要】：目的:系统评价血清CA125对卵巢上皮癌综合治疗(手术+化疗)后复发的诊断价值。方法:计算机检索Pub Med、EMBASE、Cochrane Library、Web of Science、中国生物医学文献数据库(CBM)、相关期刊论文(CJFD)、中国科技期刊数据库(CSJD)、中国知网(CNKI)数据库,检验医学专业数据库:IFCC循证实验医学数据库、Medion、CRDdatabase、Bandlier Knowledge library等;灰色文献检索:中国学术会议论文库(CACP)、ISTP,检索期限自建库至2015年12月31日。收集有关血清CA125诊断卵巢上皮癌综合治疗后复发的前瞻性或回顾性队列研究。使用诊断性试验准确性质量评价工具(QUADAS)评价文献质量并提取数据,采用Meta-Disc1.4版软件进行Meta分析。结果:共纳入33篇文献,共2188例患者。Meta分析结果显示,血清CA125对卵巢上皮癌治疗后复发的诊断优势比DOR为11.77(95%Cl为7.16~19.37),灵敏度为67%(95%Cl为65%~70%),特异度为83%(95%Cl为80%~85%),阳性似然比为3.83(95%Cl为2.70~5.43),阴性似然比为0.41(95%Cl为0.35~0.49)。结论:血清CA125阴性排除"卵巢癌复发"的价值较大,而阳性诊断"卵巢癌复发"的价值有待进一步确证。
[Abstract]:Objective: to systematically evaluate the diagnostic value of serum CA125 for the recurrence of ovarian epithelial carcinoma after comprehensive treatment (surgery + chemotherapy). Methods: computer retrieval of Pub Med, EMBASE, Cochrane Library, Web of Science, Chinese biomedical literature database (CBM), Chinese journal full text data base (CJFD), Chinese Sci-tech Journal Database (CSJD), Chinese knowledge network. According to the library, the database of medical specialty: IFCC evidence-based experimental medical database, Medion, CRDdatabase, Bandlier Knowledge library, and so on; grey literature retrieval: Chinese Academic Conference argumentative Library (CACP), ISTP, and retrieval period from construction to December 31, 2015. The diagnostic test accuracy quality assessment tool (QUADAS) was used to evaluate the quality of the literature and to extract the data, and the Meta-Disc1.4 software was used for Meta analysis. Results: a total of 33 articles were included. A total of 2188 patients with.Meta analysis showed that the diagnostic advantage of serum CA125 for the recurrence of ovarian epithelial cancer was 11.77 (95%C). L was 7.16~19.37), the sensitivity was 67% (95%Cl 65%~70%), the specificity was 83% (95%Cl 80%~85%), the positive likelihood ratio was 3.83 (95%Cl 2.70~5.43), the negative likelihood ratio was 0.41 (95%Cl 0.35~0.49). Conclusion: the value of serum CA125 negative excludes the recurrence of ovarian cancer, and the value of the positive diagnosis of "ovarian cancer recurrence" needs further confirmation.
【作者单位】：广西医科大学附属肿瘤医院妇瘤科;
【基金】：教育部高校博士学科点专项基金(No:20124503110003)
【分类号】：R737.31

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