哈萨克族和汉族孕妇晚期妊娠可溶性血管内皮生长因子受体l与子痫前期的关系研究

发布时间：2018-05-31 05:04

  本文选题：子痫 + 血管内皮生长因子受体　； 参考：《中国全科医学》2017年28期

【摘要】：目的探讨哈萨克族和汉族孕妇晚期妊娠可溶性血管内皮生长因子受体1(s Flt-1)与子痫前期(PE)的关系。方法选取2015年12月—2016年4月在新疆医科大学第一附属医院产科住院并分娩的孕妇110例,其中哈萨克族PE孕妇25例(哈萨克族PE组)、汉族PE孕妇25例(汉族PE组)、哈萨克族正常妊娠孕妇30例(哈萨克族正常妊娠组)、汉族正常妊娠孕妇30例(汉族正常妊娠组)。收集4组孕妇的临床资料,采用定量反转录聚合酶联反应(qRT-PCR)测定胎盘组织中的sFlt-1表达水平。结果哈萨克族PE组孕妇体质量高于汉族正常妊娠组,差异有统计学意义(P0.05);哈萨克族PE组、汉族PE组孕妇收缩压、舒张压高于哈萨克族正常妊娠组、汉族正常妊娠组,孕周短于哈萨克族正常妊娠期、汉族正常妊娠期,新生儿体质量低于哈萨克族正常妊娠组、汉族正常妊娠组,差异有统计学意义(P0.05)。汉族PE组、汉族正常妊娠组孕妇血红蛋白高于哈萨克族PE组、哈萨克族正常妊娠组,哈萨克族PE组、汉族PE组孕妇肌酐高于哈萨克族正常妊娠组、汉族正常妊娠组,差异有统计学意义(P0.05)。汉族PE组孕妇sFlt-1表达水平高于哈萨克族PE组、哈萨克族正常妊娠组、汉族正常妊娠组,哈萨克族PE组孕妇sFlt-1表达水平高于哈萨克族正常妊娠组、汉族正常妊娠组,差异有统计学意义(P0.05);而哈萨克族正常妊娠组、汉族正常妊娠组孕妇sFlt-1表达水平比较,差异无统计学意义(P0.05)。哈萨克族重度PE、汉族重度PE、哈萨克族轻度PE、汉族轻度PE孕妇sFlt-1表达水平比较,差异无统计学意义(P0.05)。结论晚期妊娠s Flt-1可能参与了PE的发生、发展,可作为预测PE发生、发展的血液学指标,但不能作为预测PE患者病情严重程度的指标。
[Abstract]:Objective to investigate the relationship between soluble vascular endothelial growth factor receptor (VEGF) 1s Flt-1 and preeclampsia (PEI) in late pregnancy of Kazak and Han women. Methods 110 pregnant women who were hospitalized and delivered in obstetrics department of the first affiliated Hospital of Xinjiang Medical University from December 2015 to April 2016 were selected. There were 25 cases of PE pregnant women in Kazak nationality (PE group of Kazak nationality), 25 cases of PE pregnant women of Han nationality (PE group of Han nationality), 30 cases of normal pregnant women of Kazak nationality (normal pregnancy group of Kazak nationality) and 30 cases of normal pregnancy group (30 cases of normal pregnancy group of Han nationality). The clinical data of four groups of pregnant women were collected and the expression of sFlt-1 in placenta was determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Results the body mass of pregnant women in PE group of Kazak nationality was higher than that of normal pregnancy group of Han nationality (P 0.05), systolic blood pressure and diastolic pressure of pregnant women in PE group of Han nationality were higher than those of normal pregnancy group of Kazak nationality, normal pregnancy group of Han nationality, and normal pregnancy group of Han nationality. The gestational weeks were shorter than the normal gestation period of Kazak nationality and the normal gestation period of Han nationality, the body weight of newborn was lower than that of Kazak normal pregnancy group and Han nationality normal pregnancy group, the difference was statistically significant (P 0.05). The levels of hemoglobin in PE group of Han nationality, normal pregnancy group of Kazak nationality, PE group of Han nationality, and normal pregnancy group of Han nationality were higher than those of normal pregnant group of Kazak nationality, normal pregnancy group of Han nationality, and normal pregnancy group of Han nationality. The difference was statistically significant (P 0.05). The expression of sFlt-1 in pregnant women of Han nationality PE group was higher than that of Kazak group, normal pregnant group of Kazak nationality, normal pregnancy group of Han nationality, sFlt-1 expression level of pregnant women of Kazak nationality PE group was higher than that of normal pregnant group of Kazak nationality, normal pregnancy group of Han nationality, and normal pregnancy group of Han nationality. The difference was statistically significant (P 0.05), but there was no significant difference in the expression of sFlt-1 between normal pregnant women of Kazak nationality and normal pregnant women of Han nationality (P 0.05). There was no significant difference in sFlt-1 expression levels among pregnant women of Kazak nationality, Han nationality, Kazak nationality, Han nationality and Han nationality. There was no significant difference in the expression of sFlt-1 between pregnant women and pregnant women (P 0.05). Conclusion Flt-1 of late pregnancy may be involved in the occurrence and development of PE. It can be used as a hematological index to predict the occurrence and development of PE, but it can not be used as an index to predict the severity of PE.
【作者单位】： 新疆医科大学第一附属医院产科;
【基金】：新疆维吾尔自治区自然科学基金资助项目(2014211C041)
【分类号】：R714.244
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本文编号：1958399