孕晚期地诺前列酮栓引产的临床疗效及安全性:多中心回顾性分析

发布时间：2018-05-31 10:23

本文选题：地诺前列酮栓 + 缩宫素　；参考：《南方医科大学学报》2017年01期

【摘要】：目的大样本分析广东省珠三角地区5年中地诺前列酮栓用于孕晚期引产的临床疗效和安全性。方法将广东省珠三角地区使用地诺前列酮栓进行孕晚期引产的20家医院按医院级别分层,省级医院和市区级医院各选取三家医院作为研究单位。按照严格的纳入标准和剔除标准筛选出6家医院2010年1月~2014年12月1390例地诺前列酮栓引产病例作为研究组,并抽取同期957例单纯使用缩宫素引产病例作为对照组,回顾性分析地诺前列酮栓的临床疗效及安全性。结果地诺前列酮栓组的第1产程潜伏期时长为4.06±2.65 h,长于缩宫素组3.20±2.08 h,2组相比结果有统计学意义[P=0.003,95%CI(0.182,0.920)],地诺前列酮栓组活跃期及第2产程时长为1.73±1.32 h/0.49±0.37 h,短于缩宫素组2.22±1.75 h/0.54±0.43 h,两组相比结果有统计学意义[P=0.000,95%CI(-0.795,-0.363)/P=0.003,95%CI(-0.137,-0.028)],两组相比第1产程及总产程无统计学差异;两组经阴道分娩率无统计学差异;母婴不良反应发生率无统计学差异。结论孕晚期地诺前列酮栓引产的安全性与缩宫素相似,临床疗效优于缩宫素,是一种安全有效的引产方法。
[Abstract]:Objective to analyze the clinical efficacy and safety of 5-year Diloprostone suppository in late pregnancy induced labor in Pearl River Delta area of Guangdong Province. Methods Twenty hospitals in the Pearl River Delta area of Guangdong province were divided into hospital levels and three hospitals were selected as the research units for the induction of labor in the late pregnancy stage. The provincial hospitals and the urban hospitals respectively were selected as the research units. According to strict inclusion criteria and exclusion criteria, 1390 cases of induced labor induced by denoprostone suppository were selected from 6 hospitals from January 2010 to December 2014 as study group, and 957 cases of labor induced by oxytocin were selected as control group during the same period. The clinical efficacy and safety of dinoprostone suppository were analyzed retrospectively. Results the latency of the first stage of labor was 4.06 卤2.65 hours in the desitroprostone suppository group, which was significantly longer than that in the oxytocin group (3.20 卤2.08 h) [P < 0.003]. The active period and the second stage of labor were 1.73 卤1.32 h / 0.49 卤0.37 h, and 2.22 卤1.75 h respectively in the desnoprostone suppository group (P < 0.003), and the duration of the second stage of labor was 1.73 卤1.32 h / 0.49 卤0.37 h in the denoprostone suppository group, which was significantly longer than that in the oxytocin group (3.20 卤2.08 h). H / r 0.54 卤0.43 h, the results of the two groups were statistically significant (P < 0.000 ~ 95). There was no significant difference between the two groups in the first stage of labor and the total stage of labor. There was no significant difference in the rate of vaginal delivery between the two groups, and there was no significant difference in the incidence of adverse reactions between mother and infant. Conclusion the safety of diloprostone suppository is similar to oxytocin, and the clinical efficacy is better than oxytocin. It is a safe and effective method for induced labor.
【作者单位】：南方医科大学南方医院妇产科;顺德第一人民医院妇产科;番禺何贤纪念医院妇产科;番禺中心医院妇产科;广州医科大学附属第三医院妇产科;中山大学孙逸仙纪念医院妇产科;
【基金】：广东省高等教育“创新强校工程”专项资金
【分类号】：R719.3

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