克罗米芬联合二甲双胍治疗多囊卵巢综合征的疗效观察

发布时间：2018-05-31 18:19

本文选题：克罗米芬 + 二甲双胍　；参考：《中国药房》2015年29期

【摘要】：目的:观察克罗米芬联合二甲双胍用于治疗多囊卵巢综合征(PCOS)的疗效。方法:选择PCOS患者112例,按照随机数字表法分为对照组和观察组,各56例。对照组患者给予克罗米芬治疗,自月经第5天开始口服,1次/d,50 mg/次;观察组患者在对照组基础上加用二甲双胍,进餐前半小时口服,3次/d,500 mg/d。两组疗程均为2个月。观察两组患者的生化指标、疾病控制时间、实际用药时间、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)及临床疗效。结果:治疗后,观察组患者促黄体生成素、促卵泡生成素、睾酮及空腹胰岛素水平较治疗前降低且低于对照组,差异有统计学意义(P0.05);疾病控制时间和实际用药时间较对照组缩短,差异有统计学意义(P0.05);HOMA-IR、HOMA-β均低于对照组,差异有统计学意义(P0.05);观察组患者的临床有效率显著高于对照组,差异有统计学意义(P0.05)。结论:克罗米芬联合二甲双胍用于PCOS,可明显改善患者生化指标,缩短疾病控制时间及实际用药时间,提高临床疗效。
[Abstract]:Objective: to observe the efficacy of clomiphene combined with metformin in the treatment of polycystic ovary syndrome (PCOS). Methods: 112 patients with PCOS were randomly divided into control group and observation group with 56 cases each. The patients in the control group were treated with clomiphene 50 times a day since the 5th day of menstruation. The patients in the observation group were given metformin plus metformin three times a day before meal. The course of treatment in both groups was 2 months. The biochemical indexes, disease control time, actual medication time, insulin resistance index (HOMA-IRN), insulin secretion index (HOMA- 尾) and clinical efficacy were observed. Results: after treatment, the levels of luteinizing hormone, follicle stimulating hormone, testosterone and fasting insulin in the observation group were lower than those in the control group. The difference was statistically significant (P 0.05), the time of disease control and actual medication was shorter than that of the control group, and the difference was statistically significant (P 0.05). The clinical effective rate of the observation group was significantly higher than that of the control group, and the difference was significantly lower than that of the control group (P 0.05), the clinical effective rate of the observation group was significantly higher than that of the control group. The difference was statistically significant (P 0.05). Conclusion: clomiphene combined with metformin can significantly improve the biochemical indexes of patients, shorten the time of disease control and actual drug use, and improve the clinical efficacy.
【作者单位】：南充市中心医院妇产科;
【分类号】：R711.75

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