HSF1与XAF1基因在子宫内膜癌组织中的表达及其相关性分析

发布时间：2018-06-02 11:53

本文选题：子宫内膜癌 + 热休克转录因子　；参考：《西安交通大学学报(医学版)》2015年02期

【摘要】：目的检测HSF1与XAF1基因在子宫内膜组织中的表达,分析其与临床病理学特征的关系。方法采用免疫组织化学S-P法检测64例子宫内膜癌组织(EC组)、33例正常子宫内膜组织(NE组)中两者的表达情况,并观察其相关性。结果子宫内膜癌组织中HSF1阳性表达率为76.6%,显著高于正常子宫内膜组织36.4%(P0.05);子宫内膜癌及正常子宫内膜组织XAF1阳性率分别为31.2%和72.7%,差别具有统计学意义(P0.05);在EC组中HSF1的阳性表达率在不同的组织学分级、肌层浸润及淋巴结转移间差异有统计学意义(P0.05);在EC组中XAF1的阳性表达率在不同的组织学分级、肌层浸润、手术病理分期及淋巴结转移间差异有统计学意义(P0.05);子宫内膜癌组织中HSF1与XAF1表达水平呈负相关(P0.05)。结论在子宫内膜癌组织中HSF1的高表达可能通过抑制XAF1的表达致使细胞过度生长,抑制肿瘤细胞发生凋亡,导致肿瘤进一步发展。
[Abstract]:Objective to detect the expression of HSF1 and XAF1 genes in endometrium and to analyze their relationship with clinicopathological features. Methods Immunohistochemical S-P method was used to detect the expression of both of them in 64 cases of endometrial carcinoma in group C (n = 33) and normal endometrium group (n = 33), and the correlation between them was observed. Results the positive rate of HSF1 in endometrial carcinoma was 76.6, which was significantly higher than that in normal endometrial tissue (36.4%, P 0.05), and the positive rate of XAF1 in endometrial carcinoma and normal endometrial tissue was 31.2% and 72.7, respectively, and the difference was statistically significant (P 0.05), and that in EC group was significantly higher than that in normal endometrial tissue (P 0.05). The positive expression rate of BALB was detected in different histological grades. There were significant differences in myometrial invasion and lymph node metastasis (P 0.05), and the positive expression rate of XAF1 in EC group was different in histological grade and muscle layer infiltration. There were significant differences in pathological stage and lymph node metastasis between them (P 0.05), and the expression of HSF1 and XAF1 in endometrial carcinoma was negatively correlated with that in endometrial carcinoma (P 0.05). Conclusion the overexpression of HSF1 in endometrial carcinoma may result in the over-growth of cells and the apoptosis of tumor cells by inhibiting the expression of XAF1, which may lead to the further development of tumor.
【作者单位】：第四军医大学附属西京医院妇产科;
【基金】：国家自然科学基金(No.81172458/H1621) 陕西省重点课题资助项目(No.2012KTCL03-08)~~
【分类号】：R737.33

【参考文献】