间苯三酚联合益母草制剂对青少年痛经患者前列腺素E2水平、前列腺素F2α水平、子宫微循环变化指标及临床疗效的影响

发布时间：2018-06-03 01:13

本文选题：间苯三酚 + 益母草制剂　；参考：《中国生化药物杂志》2016年01期

【摘要】：目的探讨间苯三酚联合益母草制剂对青少年痛经患者前列腺素E2(prostaglandin E2,PGE2)水平、前列腺素F2α(prostaglandin F2α,PGF2α)、子宫微循环变化指标及临床疗效的影响。方法收集浙江省淳安县妇幼保健院收治的青少年原发性痛经患者60例,根据用药不同分为对照组和实验组,每组30例,对照组于月经来潮前1d给予氟芬那酸片200 mg,3次/天,口服,服用2~3 d或至症状消失;实验组患者月经来潮前3~4d给予益母草颗粒15 g,2次/天,口服,连续服用15d;月经来潮时给予间苯三酚注射液40 mg肌内注射。2组患者均治疗3个月经周期。治疗结束后,对所有患者的血清PGE2、PGF2α水平、子宫微循环相关指标及临床疗效情况进行检测。结果与对照组治疗后比较,实验组患者血清PGE2水平明显较高(P0.05),血清PGF2α水平及PGF2α/PGE2值较低(P0.05);实验组患者的子宫动脉PI值、RI值及A/B值较低(P0.05);实验组患者总有效率较高(P0.05)。结论间苯三酚联合益母草制剂能够显著提高青少年痛经患者血清PGE2水平,降低血清PGF2α水平及PGF2α/PGE2比值,改善子宫微循环,提高临床疗效。
[Abstract]:Objective to investigate the effects of phloroglucinol combined with Leonurus preparation on the levels of prostaglandin E _ 2 (PGE _ 2), prostaglandin F _ 2 伪 (PGF _ 2 伪), the changes of uterine microcirculation and the clinical efficacy of prostaglandin E _ 2 (PGE _ 2) in young patients with dysmenorrhea. Methods 60 patients with primary dysmenorrhea were divided into control group (n = 30) and experimental group (n = 30). The control group (n = 30) was given flufenac tablets (200 mg / day) 1 day before menstruation. The patients in the experimental group were given Motherwort granule 15 g / d twice a day for 3 days before menorrhagia, or until the symptoms disappeared, and the patients in the experimental group were given 15 g of Motherwort granules twice a day. All patients were treated for 3 menstrual cycles after continuous administration for 15 days and intramuscular injection of 40 mg phloroglucinol injection for 3 menstrual cycles during menstrual onset. After the treatment, the serum PGE2 + PGF2 伪 levels, uterine microcirculatory parameters and clinical efficacy were measured. Results compared with the control group, the levels of serum PGE2, PGF2 伪 and PGF2 伪 / PGE2 in the experimental group were significantly higher than those in the control group (P 0.05), and the Pi values, RI and A / B values of the uterine artery in the experimental group were lower than those in the control group, and the total effective rate of the patients in the experimental group was higher than that in the control group (P 0.05). Conclusion Phloroglucinol combined with Leonurus preparation can significantly increase serum PGE2 level, decrease serum PGF2 伪 level and PGF2 伪 / PGE2 ratio, improve uterine microcirculation and improve clinical efficacy in patients with dysmenorrhea.
【作者单位】：浙江省淳安县妇幼保健院妇产科;浙江中医药大学附属第三医院妇产科;
【分类号】：R711.51

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