不孕不育患者临床支原体属感染分析

发布时间：2018-06-04 02:23

本文选题：女性生殖道 + 不孕症　；参考：《中华医院感染学杂志》2015年10期

【摘要】：目的了解不孕不育女性泌尿生殖道支原体属感染及药敏情况,以指导临床合理用药。方法选取2010年1月-2013年12月就诊于妇产科的1 862例不孕不育女性患者为试验组,另选同期行健康体检的1 800名女性志愿者为对照组,两组患者均采用上海奥普生物医药有限公司生产的支原体属培养鉴定药敏试剂盒,用液体培养的方法分离鉴定解脲脲支原体(Uu)和人支原体(Mh),并行药敏试验。结果对照组1 862例患者宫颈分泌物支原体培养阳性有715例,阳性率为38.4%,其中单纯UU阳性检出最多,且支原体属感染患者年龄集中在25~40岁;与对照组相比,不孕不育女性单纯Uu感染率、单纯Mh感染率和Uu+Mh混合感染率均显著增高,差异有统计学意义(P0.05);试验组对米诺环素、多西环素、交沙霉素耐药性低,对罗红霉素、阿奇霉素、喹诺酮类药物耐药性高,且四环素类抗菌药物在Uu+Mh混合感染中耐药率显著上升。结论不孕不育女性患者支原体属感染率较高,且大多数为育龄期妇女,对交沙霉素、米诺环素和多西环素敏感度高,可作为治疗支原体属感染的首选药物。
[Abstract]:Objective to investigate mycoplasma infection and drug sensitivity in infertile women. Methods from January 2010 to December 2013, 1 862 infertile female patients in gynecology and obstetrics department were selected as experimental group, and 1 800 female volunteers who underwent physical examination in the same period were selected as control group. The two groups of patients were tested by Ureaplasma Urealyticum Ureaplasma Urealyticum Ureaplasma Urealyticum Ureaplasma Urealyticum Ureaplasma Urealyticum Ureaplasma Urealyticum Ureaplasma Urealyticum Ureaplasma Urealyticum and Mycoplasma hominis Mhlum. Results the positive rate of mycoplasma in cervical secretion was 38.4% in the control group (715 cases), and the UU positive rate was the most, and the age of mycoplasma infection was 2540 years old, compared with the control group, the positive rate of mycoplasma was 38.4%, and the age of mycoplasma infection was 2540 years old. The infection rates of UU, Mh and UU Mh mixed infection in infertile women were significantly higher than those in control group (P 0.05), the drug resistance to minocycline, doxycycline and josamycin in the experimental group was low, and the drug resistance to roxithromycin and azithromycin was lower than that in the control group. The drug resistance of quinolones was high, and the resistance rate of tetracycline antibiotics in UU Mh mixed infection increased significantly. Conclusion the infection rate of mycoplasma in infertile women is high, and most of them are women of childbearing age. They are sensitive to josamycin, minocycline and doxycycline, and can be used as the first choice for the treatment of mycoplasma infection.
【作者单位】：宜昌市三峡大学人民医院;宜昌市第一人民医院妇产科;宜昌市第一人民医院检验科;
【基金】：湖北省科技厅科研基金资助项目(A14301)
【分类号】：R711.6

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