中药补肾调冲法联合冻存淋巴细胞治疗复发性流产的临床观察

发布时间：2018-06-05 09:15

本文选题：复发性流产 + 冻存淋巴细胞主动免疫治疗　；参考：《南京中医药大学》2017年硕士论文

【摘要】：目的:研究中药补肾调冲法联合冻存淋巴细胞治疗同种免疫不足不明原因复发性流产患者的临床疗效。方法:246例同种免疫不足不明原因复发性流产患者,知情同意原则自愿选择治疗方式,分为治疗组(n=86例)、对照组1(n=76例)和对照组2(n=67例),脱落及治疗中剔除患者17例。治疗组给予中药补肾调冲法联合冻存淋巴细胞及黄体支持;对照组1给予中药补肾调冲法和黄体支持;对照组2仅给予黄体支持治疗。计算治疗组封闭抗体转阳率,通过比较三个组别的妇娠成功率、中医症状改善疗效、早期血HCG及雌二醇升幅水平,以及三个组别的活产率,评价中药补肾调冲法联合冻存淋巴细胞治疗复发性流产患者的临床疗效。结果:1.治疗组86例患者,第一疗程转阳率55.8%,第二疗程转阳率76.3%,累计阳率89.5%。2.治疗组、对照组1和对照组2妊娠成功率分别为87.2%、78.9%和65.7%。与对照组1和对照组2相比,治疗组妊娠成功率显著增加,差异具有统计学意义(P0.05)。3.三组妊娠成功患者早期血HCG及E2升幅水平比较,治疗组血激素升幅水平优于对照组1和对照组2,异具有统计学意义(P0.05)。4.三组中医单项症状疗效比较,治疗组中医症状改善优于对照组1和对照组2,差异具有统计学意义(P0.05)。5.随访已产妇,计算活产率,三组活产率别为80.3%、64.8%和46.7%,三组相比差异具有统计学意义(P0.05)。结论:中药补肾调冲法联合冻存淋巴细胞治疗同种免疫不足不明原因复发性流产可明显提高治疗妊娠率,活产率高,未见明显不良反应,母儿安全性良好。
[Abstract]:Objective: to study the clinical effect of tonifying kidney and regulating chong method combined with cryopreserved lymphocytes in the treatment of recurrent abortion of unknown cause of alloimmune deficiency. Methods two hundred and six cases of recurrent abortion with unknown cause of alloimmune deficiency were randomly divided into two groups: treatment group (86 cases), control group (1(n=76) and control group (2(n=67). 17 cases were excluded from the treatment. The treatment group was treated with tonifying kidney and tonifying the kidney combined with cryopreserved lymphocyte and luteal body support; the control group 1 was treated with tonifying kidney and regulating luteal body support; the control group only received luteal support therapy. The positive rate of blocking antibody in the treatment group was calculated. By comparing the success rate of pregnant women in three groups, the curative effect of TCM symptom improvement, the levels of serum HCG and estradiol in early stage, and the live birth rate of the three groups, Objective: to evaluate the clinical effect of tonifying kidney and tonifying the kidney combined with cryopreserved lymphocytes in the treatment of recurrent abortion. The result is 1: 1. In the treatment group, 86 patients, the first course of treatment turned positive rate 55.8, the second course of treatment turned positive rate 76.3um, the cumulative positive rate 89.5. The success rate of pregnancy in treatment group, control group 1 and control group 2 was 87.2% and 65.7%, respectively. Compared with control group 1 and control group 2, the success rate of pregnancy in treatment group was significantly increased, and the difference was statistically significant (P 0.05. 3). The serum levels of HCG and E2 were higher in the treatment group than in the control group 1 and 2, respectively, and the difference was statistically significant (P 0.05. 4). The improvement of TCM symptoms in the treatment group was better than that in the control group (1) and the control group (2). The difference was statistically significant (P 0.05). The live birth rate of the three groups was 80.3% and 46.7%, respectively. The difference between the three groups was statistically significant (P 0.05). Conclusion: the combined therapy of tonifying kidney and tonifying the kidney combined with cryopreserved lymphocytes in the treatment of recurrent abortion of unknown cause of alloimmune deficiency can obviously improve the rate of pregnancy, live birth rate, no obvious adverse reaction, and good safety of mother and infant.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R714.21

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