促排卵治疗中卵泡黄素化PCOS不孕患者血清甲状腺激素水平变化及意义

发布时间：2018-06-06 02:27

本文选题：多囊卵巢综合征 + 不孕症　；参考：《山东医药》2015年27期

【摘要】：目的观察促排卵治疗中卵泡黄素化多囊卵巢综合征(PCOS)不孕患者血清甲状腺激素水平变化,并探讨其临床意义。方法对89例PCOS患者用促排卵药物(CC/HCG)诱发排卵,其中卵泡直径至18~20 mm并正常排出者49例为对照组,卵泡未能排出、出现黄素化40例为黄素化组。检测两组不同卵泡生长时期血清甲状腺激素水平。结果卵泡直径至5、10、15 mm时,两组甲状腺激素水平差异无统计学意义;卵泡直径至20 mm时,黄素化组T3、T4、TSH水平分别为(1.97±0.17)nmol/L、(97.43±0.16)nmol/L、(3.43±0.10)μIU/m L,对照组分别为(2.69±0.15)nmol/L、(124.38±0.29)nmol/L、(1.38±0.18)μIU/m L,两组T3、T4、TSH水平相比,P均0.05。结论促排卵治疗中发生卵泡黄素化的PCOS不孕患者血清T3、T4水平下降,TSH水平升高,甲状腺激素变化可能与患者排卵功能异常有关。
[Abstract]:Objective to observe the changes of serum thyroid hormone levels in infertile women with follicular luteinizing polycystic ovary syndrome (PCOS) during ovulation promotion and to explore its clinical significance. Methods the ovulation was induced by CC-HCG in 89 patients with PCOS. Among them, 49 cases with follicular diameter up to 1820 mm and normal excretion were as control group, follicular failure and luteinization were found in 40 cases as control group. Serum thyroid hormone levels were measured at different follicular growth stages in the two groups. Results there was no significant difference in thyroid hormone levels between the two groups when the follicle diameter was 510nmol / L, the T3nmol / L ~ (4) T _ (4) T _ (3) T _ (4) T _ (4) T _ (th) in the luteinized group was 1.97 卤0.17 nmol / L ~ (3) 卤0.16 nmol / L ~ (3.43 卤0.10) 渭 IU/m / L, respectively, and that in the control group was 2.69 卤0.15 nmol / L ~ (-1) 124.38 卤0.29 nmol / L ~ (1.38 卤0.18) 渭 IU/m / L, respectively, and there was significant difference between the two groups in the levels of T _ (3) T _ (4nmol / L) ~ (th) and T _ (3) T _ (4nmol / L) ~ (1.38 卤0.18) 渭 IU/m / L, respectively. Conclusion the serum T _ 3 T _ 4 level in patients with follicular luteinization in ovulation stimulating therapy was decreased and the level of TSH was increased. The changes of thyroid hormone may be related to the abnormal ovulation function of the patients.
【作者单位】：遵化市中医医院;河北联合大学附属医院;
【基金】：河北省科技计划项目(12277736)
【分类号】：R711.75

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