Th17和Treg细胞及其比例在先兆流产中的变化及意义

发布时间：2018-06-07 16:18

本文选题：Th细胞 + 先兆流产　；参考：《免疫学杂志》2015年05期

【摘要】：目的检测外周血Th17细胞和调节性T细胞(Treg细胞)在先兆流产发病机制中的作用。方法入组健康早孕妇女24例和先兆流产孕妇37例,采用三色荧光流式细胞分析技术检测2组孕妇外周血中Th17细胞和Treg细胞占CD4+T细胞的比例,使用SPSS16.0分析相关数据。结果先兆流产孕妇与健康早孕妇女既往均无自然流产史,外周血中,先兆流产孕妇Th17细胞占CD4+T细胞的比例显著高于健康早孕妇女(P0.05),而Treg细胞占CD4+T细胞的比例显著低于健康早孕妇女(P0.05),且Th17/Treg细胞比例在先兆流产孕妇中明显升高(P0.05)。结论外周血Th17和Treg细胞水平异常及两者比例失衡可能参与先兆流产的发生。
[Abstract]:Objective to investigate the role of peripheral blood Th17 cells and regulatory T cell Treg cells in the pathogenesis of threatened abortion. Methods Twenty-four healthy women with early pregnancy and 37 pregnant women with threatened abortion were enrolled in this study. The percentage of Th17 cells and Treg cells in CD4 T cells in peripheral blood of pregnant women in two groups were detected by three-color fluorescence flow cytometry (FCM). The relevant data were analyzed by SPSS16.0. Results both threatened abortion and healthy early pregnancy had no history of spontaneous abortion. The percentage of Th17 cells in CD4 T cells in pregnant women with threatened abortion was significantly higher than that in healthy women with early pregnancy, while the proportion of Treg cells in CD4 T cells was significantly lower than that in healthy early pregnant women. The proportion of Th17/Treg cells in pregnant women with threatened abortion was significantly higher than that in pregnant women with threatened abortion. Conclusion the abnormal levels of Th17 and Treg cells in peripheral blood and their imbalance may be involved in the occurrence of threatened abortion.
【作者单位】：山西医科大学基础医学院微生物与免疫学教研室;山西大同大学免疫学研究所;山西省大同市第五人民医院麻醉科;山西大同大学医学院外科实验室;山西省大同市第三人民医院产科;
【基金】：国家自然科学基金(81170621)
【分类号】：R714.21

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