早孕期孕酮水平的回顾性研究

发布时间：2018-06-07 22:10

本文选题：早孕期 + 孕酮　；参考：《中国妇产科临床杂志》2017年03期

【摘要】：目的比较正常妊娠结局和胚胎停育孕妇的早孕期孕酮水平,并随访早孕期孕激素补充治疗的安全性。方法回顾性分析了2015年1月至2月在北京协和医院分娩的144例孕妇的孕期资料,并与同期行孕酮检测的53例胚胎停育患者的病例资料进行比较,统计分析了早孕期孕酮的参考范围及影响因素;对接受孕激素治疗患者试图评估其安全性。结果正常妊娠人群的早孕期孕酮正常低限为11 ng/ml,孕酮水平与患者的年龄、甲状腺功能、是否合并糖尿病、是否有先兆流产症状、孕周并未发现相关性。胚胎停育患者孕酮水平与正常妊娠孕妇无显著差别,但发生胚胎停育近期监测的孕酮水平可有明显下降。使用孕激素治疗可能与胎盘粘连有关。结论亟需建立早孕期孕酮的正常参考范围以规范对孕酮水平的解释;需关注孕激素补充治疗与胎盘粘连的相关性。
[Abstract]:Objective to compare the levels of progesterone in early pregnancy with normal pregnancy outcome and embryo arrest, and to follow up the safety of progesterone supplementation in early pregnancy. Methods the pregnant data of 144 pregnant women who gave birth in Beijing Union Hospital from January to February 2015 were analyzed retrospectively, and the data of 53 cases of aborted embryo with progesterone were compared. The reference range and influencing factors of progesterone in early pregnancy were statistically analyzed, and the safety of progesterone was evaluated in patients treated with progesterone. Results the normal limit of progesterone in early pregnancy was 11 ng / ml. There was no correlation between progesterone level and age, thyroid function, diabetes mellitus, threatened abortion, gestational week. There was no significant difference in progesterone level between normal pregnant women and normal pregnant women, but the progesterone level monitored in the near term was significantly decreased. Progesterone therapy may be associated with placental adhesion. Conclusion it is urgent to establish the normal reference range of progesterone in early pregnancy in order to standardize the explanation of progesterone level and to pay attention to the correlation between progesterone supplementation therapy and placental adhesion.
【作者单位】：中国医学科学院北京协和医院妇产科;
【分类号】：R714.2

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