非肥胖孕妇血清C-反应蛋白水平与妊娠期糖尿病相关性研究

发布时间：2018-06-09 04:14

本文选题：妊娠期糖尿病 + C-反应蛋白　；参考：《中国实用妇科与产科杂志》2015年01期

【摘要】：目的探讨非肥胖孕妇血清C-反应蛋白(CRP)水平与妊娠期糖尿病(GDM)的相关性,了解CRP对妊娠期糖尿病是否存在临床预测意义。方法选取2011年8月至2012年12月大连大学附属中山医院和中山区妇保院孕前基础体重指数均25的孕妇,分为妊娠期糖尿病组(GDM组)、正常组(NGT组),每组各90例。比较不同组别之间指标的差异及影响血清CRP的相关因素。结果 GDM组血清CRP水平明显高于NGT组,差异有统计学意义(P0.01)。血清CRP水平与胰岛素抵抗指数、孕期体重增长、空腹血糖、孕前基础体重及孕前体重指数均呈正相关,相关系数分别为0.377、0.333、0.276、0.278、0.300(均为P0.01)。通过多元线性回归分析,采用Backward法,其CRP(y)的直线回归方程为y=0.323X1+0.1X2+0.244X3-3.918,r2=0.263(X1胰岛素抵抗指数,X2孕期体重增长,X3孕前体重指数)。结论血清C-反应蛋白对妊娠期糖尿病的独立影响不能被证实。控制孕期体重增长有助于预防妊娠期糖尿病的发生。
[Abstract]:Objective to investigate the correlation between serum C-reactive protein (CRP) level and GDM in non-obese pregnant women, and to understand whether CRP has clinical predictive significance in gestational diabetes mellitus (GDM). Methods pregnant women in Zhongshan Hospital affiliated to Dalian University and Zhongshan District Women's Insurance Hospital from August 2011 to December 2012 were divided into GDM group and NGT group with 90 cases in each group. To compare the difference of indexes between different groups and the related factors affecting serum CRP. Results the serum CRP level in GDM group was significantly higher than that in NGT group (P 0.01). Serum CRP levels were positively correlated with insulin resistance index, weight gain during pregnancy, fasting blood glucose, basal body weight before pregnancy and body mass index before pregnancy, with correlation coefficients of 0.377U 0.333U 0.276U 0.278g 0.300 (all P 0.01). By multivariate linear regression analysis, the linear regression equation of the CRPY was: YYI 0.323X1 0.1X2 0.244X3-3.918r2X 0.263X 1 insulin resistance index (IGR) during pregnancy and body mass index (BMI) before gestation. Conclusion the independent effect of serum C-reactive protein on gestational diabetes mellitus can not be confirmed. Controlling weight gain during pregnancy helps prevent gestational diabetes.
【作者单位】：大连大学附属中山医院妇产科;
【基金】：大连市卫生局课题[大卫科发(2011)178]
【分类号】：R714.256

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