发病年龄对子宫内膜癌预后的影响

发布时间：2018-06-09 06:46

本文选题：子宫内膜癌 + 预后　；参考：《广东医学》2015年07期

【摘要】：目的探讨不同年龄对子宫内膜癌预后的影响。方法对2000—2010年广东省子宫内膜癌防治项目协作医院收集并追踪到的5 690例子宫内膜癌患者进行回顾性分析。结果 (1)2000—2010年子宫内膜癌平均发病年龄相对平稳,未见明显上升和下降趋势。(2)随着年龄增大,子宫内膜癌患者合并糖尿病、高血压的比例呈上升趋势,出现特殊组织学类型、组织学分级G3、深肌层浸润等的发生率增大。(3)≤40岁、41~45岁、46~50岁、51~55岁、56~60岁、61~65岁、65岁患者的5年总体生存率分别为96.8%、98.0%、94.7%、91.4%、91.3%、86.3%、83.8%,差异有统计学意义(P0.001);5年无进展生存率分别为94.7%、95.9%、91.9%、87.3%、87.6%、83.0%、77.4%,差异有统计学意义(P0.001)。Cox多因素分析显示发病年龄50岁(P0.05)是子宫内膜癌的独立预后因素。结论子宫内膜癌发病未见明显年轻化趋势。年龄是子宫内膜癌的独立预后因素,老年患者的预后比年轻患者差。
[Abstract]:Objective to investigate the effect of different ages on the prognosis of endometrial carcinoma. Methods A retrospective analysis of 5 690 endometrial cancer patients collected and tracked by Guangdong Provincial endometrial Cancer Project Cooperation Hospital from 2000 to 2010 was carried out. Results the mean onset age of endometrial carcinoma from 2000 to 2010 was relatively stable, but there was no obvious rising and descending trend. (2) with the age increasing, the proportion of hypertension in endometrial carcinoma patients with diabetes mellitus was increasing, and the special histological type appeared. Histopathological grade G3, deep myometrium infiltration, etc.) the overall 5-year survival rate of patients aged 65 or 65 was 96.898.00.The overall 5-year survival rate was 96.898.09.71.4, 91.36.36.33.83.83.80.The 5-year progressionless survival rate was 94.79.99.99.99.97.3m and 91.99.97.3m, respectively. The 5-year progression-free survival rate was 94.79.99.99.97.30.The 5-year survival rate was 94.79.995. 91.91.97.30.The overall survival rate of the patients aged 65 and 65 was 94.898.0% and 87.36% respectively, and the difference was 77.40.The 5-year progression-free survival rate was 94.79.995. 99.97.37.33%, respectively. Multivariate analysis showed that age of onset was 50 years old and P0.05) was an independent prognostic factor of endometrial carcinoma. Conclusion the incidence of endometrial carcinoma is not significantly younger. Age is an independent prognostic factor for endometrial carcinoma, and the prognosis of elderly patients is worse than that of young patients.
【作者单位】：中山大学附属第三医院妇科;
【基金】：国家自然科学基金资助项目(编号:30772332) 广东省自然科学基金资助项目(编号:S2012010008640) 广东省妇幼安康工程——子宫内膜癌防治项目
【分类号】：R737.33

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