血清肿瘤标记物在卵巢癌诊断和监控治疗中的应用价值

发布时间：2018-06-10 09:14

本文选题：卵巢癌 + 肿瘤标记物　；参考：《广东医学》2017年S1期

【摘要】：目的探讨血清肿瘤标记物在卵巢癌诊断及监控中的应用价值。方法选取收治的60例卵巢癌患者、60例卵巢良性肿瘤患者分别设置为卵巢癌组、卵巢良性肿瘤组,另选取同期在我院接受健康体检的体检正常妇女60例作为对照组,对其血清肿瘤标记物的表达水平进行测定和比较,并计算各单项血清肿瘤标记物检测对卵巢癌的辅助诊断结果。结果 3组受检者的血清癌胚抗原(CEA)、3种糖类抗原(CA125、CA153、CA199)、人附睾蛋白4(HE4)等肿瘤标记物的表达水平进行比较,差异均有统计学意义(P0.05);5种血清肿瘤标记物单项检测对卵巢癌的辅助诊断灵敏度、特异度、准确性进行比较,差异均无统计学意义(P0.05)。结论血清肿瘤标记物的表达水平可反映卵巢癌病变,对其实施联合检测有利于提高卵巢癌的检出率,可作为卵巢癌早期诊断的参考依据。
[Abstract]:Objective to evaluate the value of serum tumor markers in diagnosis and monitoring of ovarian cancer. Methods 60 patients with ovarian cancer and 60 patients with benign ovarian tumor were divided into ovarian cancer group and ovarian benign tumor group, and 60 normal women who received physical examination in our hospital at the same time were selected as control group. The expression level of serum tumor markers was measured and compared, and the auxiliary diagnostic results of each single serum tumor marker for ovarian cancer were calculated. Results the expression levels of tumor markers such as CA125, CA153, CA153, and human epididymal protein 4 were compared among the serum carcinoembryonic antigen (CEA) and three kinds of carbohydrate antigens (CA125, CA153, CA199) and human epididymal protein (H4), respectively. There were significant differences in the sensitivity, specificity and accuracy of the five serum tumor markers in the diagnosis of ovarian cancer. There was no significant difference in the sensitivity, specificity and accuracy of the five serum tumor markers. Conclusion the expression level of serum tumor markers can reflect the pathological changes of ovarian cancer. The combined detection of tumor markers can improve the detection rate of ovarian cancer and can be used as a reference for early diagnosis of ovarian cancer.
【作者单位】：武汉市第一医院妇科;
【分类号】：R737.31

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