WT1和VEGF在上皮性卵巢癌组织中的表达及临床意义

发布时间：2018-06-10 12:52

本文选题：肾母细胞瘤基因 + 血管内皮生长因子　；参考：《中国老年学杂志》2017年22期

【摘要】：目的探讨肾母细胞瘤基因(WT1)和血管内皮生长因子(VEGF)在上皮性卵巢癌组织中的表达及临床意义。方法经手术切除的50例原发性上皮性卵巢癌组织标本,另选取同期获得的20例良性卵巢肿瘤组织标本和20例正常卵巢组织标本。采用免疫组化SP法对所有组织标本中的WT1和VEGF表达情况进行测定,并结合患者的病理资料进行综合分析。结果卵巢癌、良性卵巢肿瘤和正常卵巢组织WT1阳性率分别为66.0%、10.0%和5.0%,VEGF阳性率分别为74.0%、30.0%和15.0%。WT1和VEGF均在卵巢癌组织中阳性表达最高(P0.05);卵巢癌组织中WT1的表达与病理分期、病理分级和病理类型有关(P0.05),与年龄和淋巴转移无关(P0.05);VEGF的表达则与病理分期有关(P0.05),与年龄、病理分级、病理类型和淋巴转移均无关(P0.05);卵巢癌组织中WT1与VEGF的阳性表达呈正相关(r=0.728,P0.05)。结论 WT1和VEGF均在上皮性卵巢癌的发生发展和侵袭中起到了重要作用,且两者表达呈正相关,可作为卵巢癌诊断、预后判断的重要指标。
[Abstract]:Objective to investigate the expression and clinical significance of Wilms tumor gene (WT1) and vascular endothelial growth factor (VEGF) in epithelial ovarian carcinoma. Methods 50 cases of primary epithelial ovarian carcinoma were surgically resected, and 20 cases of benign ovarian tumors and 20 cases of normal ovarian tissues were collected at the same time. The expression of WT1 and VEGF in all tissues was determined by immunohistochemical SP method, and the pathological data of the patients were analyzed synthetically. Results the positive rates of WT1 in ovarian cancer, benign ovarian tumor and normal ovarian tissue were 66.0% and 5.0%, respectively. The positive rates of VEGF were 74.0% and 15.0%, respectively. The expression of VEGF was not related to age and lymphatic metastasis, but not to age, pathological grade, pathological type and lymphatic metastasis. There was a positive correlation between the expression of WT1 and VEGF in ovarian carcinoma. Conclusion WT1 and VEGF play an important role in the occurrence, development and invasion of epithelial ovarian cancer, and the expression of WT1 and VEGF are positively correlated. WT1 and VEGF can be used as an important index in the diagnosis and prognosis of ovarian cancer.
【作者单位】：三峡大学仁和医院妇产科;
【基金】：国家自然科学基金(No.81302269)
【分类号】：R737.31

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