二甲双胍联合炔雌醇环丙孕酮对不孕症患者性激素水平及妊娠的影响

发布时间：2018-06-11 14:37

本文选题：瘦型多囊卵巢综合征不孕症 + 二甲双胍　；参考：《中国地方病防治杂志》2017年05期

【摘要】：目的探讨二甲双胍联合炔雌醇环丙孕酮对海南地区瘦型多囊卵巢综合征(PCOS)不孕症患者性激素水平及妊娠的影响。方法 271例瘦型PCOS不孕症患者,根据治疗方案分为观察组(135例)与对照组(136例)。对照组给予炔雌醇环丙孕酮治疗,观察组在对照组基础上联合二甲双胍治疗。对比两组治疗前后卵泡生成激素(FSH)、黄体生成激素(LH)、雌二醇(E2)、孕酮(P)、睾酮(T)水平,治疗后随访3个月,统计两组排卵率及妊娠率。结果治疗后观察组FSH、LH、T水平低于对照组(P0.05);排卵率74.81%(101/135)、妊娠率40.74%(55/135)均高于对照组52.94%(72/136)、27.94%(38/136)(P0.05)。结论二甲双胍与炔雌醇环丙孕酮联合治疗瘦型PCOS不孕症患者,可降低性激素水平、提高排卵及妊娠率。
[Abstract]:Objective to investigate the effect of metformin combined with estradiol cycloprogestrel on sex hormone level and pregnancy in patients with PCOS in Hainan area. Methods 271 patients with thin PCOS infertility were divided into two groups according to the treatment regimen: observation group (135 cases) and control group (136 cases). The control group was treated with cyproprogesterone and the observation group was treated with metformin on the basis of the control group. The levels of follicle-forming hormone (FSH), luteinizing hormone (LHH), estradiol (E _ 2), progesterone (P), testosterone (T) were compared between the two groups before and after treatment. The ovulatory and pregnancy rates of the two groups were calculated after 3 months follow-up. Results after treatment, the level of FSHN LHN T in the observation group was lower than that in the control group (P 0.05), the ovulation rate was 74.81 / 101 / 135, and the pregnancy rate was 40.74 / 55 / 135), which was higher than that in the control group (52.94%). Conclusion Metformin combined with estradiol cycloprogestrel can reduce the level of sex hormone and increase ovulation and pregnancy rate in patients with leptic PCOS infertility.
【作者单位】：海南省妇幼保健院生殖医学中心;
【基金】：海南省自然科学基金资助项目(编号:811160)
【分类号】：R711.6

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