上海朱泾地区妊娠早期空腹血糖与妊娠期糖尿病相关性的回顾性分析

发布时间：2018-06-12 19:16

本文选题：空腹血糖 + 糖尿病　；参考：《中国糖尿病杂志》2017年04期

【摘要】：目的探讨妊娠早期FPG对GDM的预测价值。方法回顾性分析2014年于上海市第六人民医院金山分院产检和住院孕妇妊娠早期FPG水平,以及妊娠24~28周75 g OGTT资料;根据妊娠早期FPG水平对行OGTT的孕妇进行四分位分组,比较并分析妊娠早期FPG与OGTT不同时点血糖及GDM关系。结果 2165名孕妇中GDM 248例;GDM组妊娠早期FPG水平高于非GDM组[(4.86±0.48)vs(4.67±0.32)mmol/L,P0.01];仅用FPG诊断GDM患病率四分位组比较,差异有统计学意义(P0.01),仅用1 hPG或2 hPG诊断GDM患病率四分位组比较,差异无统计学意义(P0.05)。相关分析显示,妊娠早期FPG与妊娠中期FPG呈正相关(r=0.497,P0.01)。妊娠早期FPG预测仅用FPG诊断的GDM受试者工作特征(ROC)曲线下最大面积(AUC)为0.834(95%CI:0.796~0.871,P0.01),切点为5.05 mmol/L,敏感性66.7%,特异性88.4%。结论上海朱泾地区孕妇GDM患病率为11.45%;仅以妊娠早期FPG预测GDM能力较低。
[Abstract]:Objective to evaluate the predictive value of FPG in early pregnancy for GDM. Methods the FPG levels in early pregnancy and 75 g OGTT data of pregnant women in Jinshan Branch Hospital of the sixth people's Hospital of Shanghai in 2014 were analyzed retrospectively, and the four quartile groups of OGTT pregnant women were divided according to the FPG level in the first trimester of pregnancy. To compare and analyze the relationship between FPG and OGTT at different time points of blood glucose and GDM in early pregnancy. Results the level of FPG in the first trimester of 2165 pregnant women was higher than that in the non-GDM group [4.86 卤0.32 0.48)vs(4.67 卤0.32 mmol / L P0.01], the difference was statistically significant in the quartile group, the prevalence rate of GDM was only diagnosed with 1 hPG or 2 hPG. The difference was not statistically significant (P 0.05). Correlation analysis showed that there was a positive correlation between FPG in the first trimester and FPG in the second trimester. In early pregnancy, the maximum area of AUC in GDM subjects diagnosed only by FPG was 0.834 ~ 95 CI: 0.796 ~ 0.871g P0.01g, the point of cut was 5.05 mmol / L, the sensitivity was 66.7%, and the specificity was 88.488. Conclusion the prevalence rate of GDM in pregnant women in Zhujing area of Shanghai is 11.45, and the ability of predicting GDM only based on FPG in early pregnancy is lower.
【作者单位】：上海市第六人民医院金山分院内分泌代谢科;上海市第六人民医院金山分院妇产科;上海交通大学附属第六人民医院内分泌代谢科;
【基金】：上海市医学和农业领域科技支撑项目(15411953100)
【分类号】：R714.256

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