DNA甲基化与卵巢癌多药耐药及预后的关系

发布时间：2018-06-12 21:59

本文选题：DNA甲基化 + 卵巢癌　；参考：《中国肿瘤生物治疗杂志》2015年03期

【摘要】：目的:卵巢癌是严重威胁女性健康的疾病,病死率居妇科恶性肿瘤之首。多药耐药是卵巢癌患者术后化疗失败的主要原因,而DNA甲基化则是卵巢癌多药耐药调控的重要机制,因此全面了解DNA甲基化对卵巢癌多药耐药的调控机制对于卵巢癌治疗和预后具有重要意义。通过Pub Med数据库检索,笔者共提取了26个与卵巢癌多药耐药调控显著相关的DNA甲基化基因,系统整合分析了这些基因甲基化水平改变对卵巢癌耐药的影响及其分子调控机制。在所有26个基因中,至少一半以上的DNA甲基化基因直接或间接地通过调控细胞凋亡信号通路响应耐药调控,说明该信号通路可能是DNA甲基化基因行使其耐药生物学功能的主要方式。另外,分析这26个卵巢癌耐药相关甲基化基因与患者临床预后的关系,表明上述基因主要与不良预后相关。总之,深入探讨DNA甲基化基因与卵巢癌耐药和预后的潜在关系,对于充分认识DNA甲基化对卵巢癌耐药的调控及提高卵巢癌的疗效和改善预后具有一定的指导意义。
[Abstract]:Objective: ovarian cancer is a serious threat to women's health. Multidrug resistance is the main reason for the failure of chemotherapy in patients with ovarian cancer, and DNA methylation is an important mechanism for the regulation of multidrug resistance in ovarian cancer. Therefore, it is important for the treatment and prognosis of ovarian cancer to fully understand the regulatory mechanism of DNA methylation on multidrug resistance in ovarian cancer. A total of 26 DNA methylation genes associated with multidrug resistance regulation in ovarian cancer were extracted by searching the Pub Med database. The effects of these gene methylation level changes on ovarian cancer drug resistance and its molecular regulatory mechanism were systematically analyzed. Of the 26 genes, at least half of the DNA methylation genes respond to drug resistance directly or indirectly by regulating the apoptotic signaling pathway. This signal pathway may be the main way for DNA methylation gene to exercise its biological function of drug resistance. In addition, the relationship between the 26 MDR-associated methylation genes and the clinical prognosis of ovarian cancer patients was analyzed, which indicated that these genes were mainly associated with poor prognosis. In conclusion, the study of the potential relationship between DNA methylation gene and drug resistance and prognosis of ovarian cancer has certain guiding significance for fully understanding the regulation of DNA methylation on ovarian cancer resistance, improving the curative effect and improving the prognosis of ovarian cancer.
【作者单位】：广西医科大学附属肿瘤医院妇瘤科;
【基金】：高等学校博士学科点专项科研基金资助项目(No.20124503110003) 广西科学研究与技术开发计划课题(No.14124004) 广西自然科技基金(No.2014 jj AA40673)~~
【分类号】：R737.31

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