暖巢煲合来曲唑治疗PCOS排卵障碍不孕（肾虚型）的临床观察

发布时间：2018-06-13 03:33

本文选题：多囊卵巢综合征 + 暖巢煲　；参考：《湖南中医药大学》2014年硕士论文

【摘要】：目的：观察药膳方“暖巢煲”合来曲唑治疗多囊卵巢综合征(PCOS)排卵功能障碍性不孕肾虚证的临床疗效,为临床应用提供依据。方法：严格按照诊断及纳入标准,收集2013年1月～2013年8月在湖南中医药大学第一附属医院妇科门诊病人中因PCOS排卵障碍不孕肾虚证的患者60例,遵循随机、阳性药对照的科研设计方法,分为2组,治疗组30例,口服暖巢煲合来曲唑；对照组30例,单纯口服来曲唑,连续治疗3个疗程,即3个月经周期。观察2组治疗前后月经情况、中医症候积分、排卵率及妊娠率,安全性指标情况及不良反应。结果：治疗组临床痊愈15例,显效7例,有效5例,无效3例,总有效率90.00%；对照组临床痊愈8例,显效6例,有效9例,无效7例,总有效率76.67%,两组间临床疗效比较差异有统计学意义(P0.05)。治疗组排卵率为81.18%,对照组排卵率为47.73%(P0.01),差异有统计学意义,治疗组排卵率优于对照组。两组治疗后妊娠率比较,治疗组妊娠率为33.33%,对照组妊娠率为10.00%(P0.05),差异有统计学意义,两组均能使受试者月经不调情况改善及临床症状改善,且两组间月经改善情况比较有差异(P0.05),即治疗组疗效优于对照组。治疗后两组间中医症候积分比较有统计学意义(P0.05),说明在改善中医症候积分方面治疗组疗效明显高于对照组。结论：暖巢煲联合来曲唑治疗PCOS排卵障碍性不孕肾虚证可有效改善患者月经及中医症候情况,提高PCOS患者的排卵率及临床妊娠率。可为PCOS排卵功能障碍不孕的妇女提供较好的治疗方案。
[Abstract]:Objective: to observe the clinical effect of "warm nest-pot" and letrozole in the treatment of ovulation dysfunction syndrome of PCOS, and to provide the basis for clinical application. Methods: according to the criteria of diagnosis and inclusion, 60 patients with kidney deficiency due to PCOS ovulation disorder were collected from January 2013 to August 2013 in the gynecological outpatient department of the first affiliated Hospital of Hunan University of traditional Chinese Medicine. The design method of positive drug control was divided into two groups: treatment group (n = 30) and control group (n = 30). Menstruation, TCM symptom score, ovulation rate and pregnancy rate, safety index and adverse reaction were observed before and after treatment. Results: in the treatment group, 15 cases were cured, 7 cases were effective, 5 cases were effective, 3 cases were ineffective, and the total effective rate was 90.00.The control group was clinically cured in 8 cases, effective in 6 cases, effective in 9 cases, ineffective in 7 cases. The total effective rate was 76.67 and the difference between the two groups was statistically significant (P 0.05). The ovulation rate of the treatment group was 81.18 and that of the control group was 47.730.The difference was statistically significant. The ovulation rate of the treatment group was better than that of the control group. The pregnancy rate was 33.33 in the treatment group and 10.00 in the control group. The difference was statistically significant. Both groups could improve the menstrual disorder and clinical symptoms. There was significant difference between the two groups in the improvement of menstruation, that is, the curative effect of the treatment group was better than that of the control group. After treatment, the scores of TCM symptoms in the two groups were significantly higher than those in the control group (P 0.05), which indicated that the curative effect of the treatment group was significantly higher than that of the control group in improving the TCM symptom score. Conclusion: the treatment of kidney deficiency syndrome with PCOS ovulation disorder can effectively improve menstruation and TCM symptoms, and increase the ovulation rate and clinical pregnancy rate of PCOS patients. It can provide better treatment for infertile women with PCOS ovulation dysfunction.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.6

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