胎膜早破与下生殖道病原体感染相关性分析

发布时间：2018-06-13 09:31

本文选题：胎膜早破 + 感染　；参考：《中国现代医学杂志》2017年10期

【摘要】：目的探讨胎膜早破与下生殖道病原体感染的相关性。方法随机选取2014年3月至2016年3月在粤北人民医院产科产检并住院分娩的胎膜早破孕妇200例资料(研究组),选取同期在产科住院分娩的胎膜未破正常孕妇200例(对照组),分别对两组的入院C-反应蛋白(CRP)、白带常规、细菌性阴道病(BV)、沙眼衣原体(CT)、细小脲原体(UP)、人型支原体(MH)、B族溶血性链球菌(GBS)检测资料进行分析。结果研究组CRP值高于对照组(t=3.221,P=0.001);研究组UP、CT、BV、MH、GBS、白色念珠菌、滴虫及混合感染的发生率均高于对照组(χ~2=49.520,4.810,5.498,12.210,9.421,4.815,4.592,41.813,均P0.05),其中UP、MH及混合感染的发生率组间差异具有统计学意义(P0.05),下生殖道总感染率研究组(60%)高于对照组(26%)(χ~2=47.160,P=0.000);研究组新生儿早产、新生儿肺炎、新生儿窒息及新生儿病理性黄疸的发生率均高于对照组(χ~2=17.330,33.006,9.355,4.891,均P0.05),而低体重儿的发生率则差异无统计学意义(P0.05);多元相关分析结果表明,UP、MH、GBS、CT及白色念珠菌与胎膜早破发生密切相关,其中UP为相关因素(P=0.000),BV和滴虫与胎膜早破的发生无相关性(P0.05)。结论胎膜早破与下生殖道UP、MH、GBS、CT及白色念珠菌感染相关,细小脲原体感染为最主要的因素,有必要在孕前及孕期进行相关病原体筛查,针对病因采取相应防治措施,以降低胎膜早破的发生,减少母儿不良结局。
[Abstract]:Objective to investigate the relationship between premature rupture of membranes and pathogen infection in the lower genital tract. Methods 200 pregnant women with premature rupture of membranes were randomly selected from March 2014 to March 2016 in the Department of Obstetrical examination and delivery in North Guangdong people's Hospital (study group) and 200 normal pregnant women (n = 200) who gave birth in obstetrics hospital during the same period (P < 0.05). Control group, two groups of admission to the C-reactive protein (CRP), leucorrhea routine, The detection data of bacterial vaginosis (BV), Chlamydia trachomatis (CTT), small Ureaplasma Urealyticum (UPU), Mycoplasma hominis (MHU) B group hemolytic streptococcus (GBS) were analyzed. Results the CRP level in the study group was higher than that in the control group (3.221), and that in the study group was higher than that in the control group, and that in the study group was higher than that in the control group, and that in the study group was higher than that in the control group. The incidence of trichomonas and mixed infection was higher than that of the control group (蠂 ~ (2) 2) 49.520 (4.810) 5.49810 (12.21010) 9.421 (4.815) 4.592 (41.813), among which the incidence of UPMH and mixed infection was significantly higher than that of the control group (P 0.05, the total infection rate of the lower genital tract) was higher than that of the control group (蠂 ~ (2 +) 47.160P0.000); the study group had preterm delivery, neonatal pneumonia, and the study group had a significant difference in the incidence of mixed infection (P 0.05), and the lower genital tract infection rate in the study group was significantly higher than that in the control group. The incidence of neonatal asphyxia and neonatal pathological jaundice was higher than that of the control group (蠂 ~ (2) 17.330 ~ 33.006 ~ 9.355 ~ 4.891, P = 0.05), but there was no significant difference in the incidence of low birth weight infant (P = 0.05). The results of multivariate correlation analysis showed that there was a close relationship between the occurrence of premature rupture of membranes and the occurrence of premature rupture of fetal membrane by the GBSCT and Candida albicans, and the results of multivariate correlation analysis showed that the incidence of neonatal asphyxia and neonatal pathological jaundice was significantly higher than that of the control group (P < 0.05). There was no correlation between up and the occurrence of premature rupture of membranes (P 0.05). Conclusion premature rupture of membranes is related to the infection of Ureaplasma parvoplasmatis (UU) in the lower genital tract and the infection of Ureaplasma albicans. It is necessary to screen the pathogens before pregnancy and during pregnancy, and to take corresponding preventive and therapeutic measures against the etiology. In order to reduce the occurrence of premature rupture of membranes, reduce maternal and fetal adverse outcome.
【作者单位】：汕头大学附属粤北人民医院妇产科;
【分类号】：R714.433

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