宜昌地区妇女人乳头瘤病毒感染特征分析

发布时间：2018-06-13 11:37

本文选题：人乳头瘤病毒 + 基因芯片　；参考：《中华肿瘤防治杂志》2015年16期

【摘要】：目的探讨宜昌地区健康体检女性26种人乳头瘤病毒(human papillomavirus,HPV)的感染状况,并分析HPV不同亚型感染与不同宫颈病变的对应关系,同时为该地区HPV亚型的流行病学特点提供理论依据。方法选择2014-08-01-2014-10-13宜昌市中心人民医院1 008例23~78岁健康体检女性,采集宫颈脱落细胞,通过基因芯片技术分析17种高危型和9种低危型HPV亚型的分布,同时配对进行液基细胞学检查。结果 1 008例妇女中,HPV阳性者232例(23.00%),总感染型为313例。26种HPV亚型感染率前5位的分别是HPV16为14.06%(44/313),HPV58为12.46%(39/313),HPV52为9.27%(29/313),HPV54为7.35%(23/313),HPV51为6.71%(21/313)。30~35岁年龄段女性的HPV检出率为37.6%(44/117),与≤30岁(χ2=7.770,P=0.005)、35~40岁(χ2=7.682,P=0.006)、40~45岁(χ2=14.909,P0.001)、45~50岁(χ2=7.996,P=0.005)和50岁(χ2=8.875,P=0.003)比较,差异均有统计学意义;高危HPV感染率为31.6%(37/117),与≤30岁(χ2=4.544,P=0.033)、35~40岁(χ2=8.857,P=0.003)、40~45岁(χ2=11.976,P=0.001)、45~50岁(χ2=5.843,P=0.016)和50岁(χ2=7.504,P=0.006)比较,差异均有统计学意义;其中30~35岁年龄段女性的HPV检出率为37.6%(44/117),高危HPV感染率为31.6%(37/117),均最高,与其他不同年龄段人群分别比较,差异均有统计学意义,P0.05,符合流行病学特征。液基细胞学结果显示,HPV感染与宫颈上皮内病变密切相关。结论高危型HPV16、58和52型作为宜昌地区的优势型别,应纳入HPV疫苗研究重点。30~35岁妇女应列入宫颈癌前病变或子宫颈癌的重点筛查对象。
[Abstract]:Objective to investigate the infection status of 26 human papillomavirus (human papillomavirus, HPV) in healthy women in Yichang, and to analyze the relationship between different HPV subtypes and different cervical lesions, and to provide a theoretical basis for the epidemiological characteristics of HPV subtype in this area. The people's medicine in the city center of Yichang was selected by Fang method. 1008 Cases of 23~78 years old healthy women were collected from the cervical exfoliative cells. The distribution of 17 high risk types and 9 low risk type HPV subtypes was analyzed by gene chip technology. At the same time, the liquid based cytological examination was performed. Among the 1008 women, 232 cases (23%) were HPV positive, and the total infection type was H and the first 5 of the HPV subtypes were H, respectively. PV16 is 14.06% (44/313), HPV58 is 12.46% (39/313), HPV52 is 9.27% (29/313), HPV54 is 7.35% (23/313), HPV51 is 6.71% (21/313), and the HPV detection rate is 37.6% (37.6%). P=0.003), the difference was statistically significant; the high risk HPV infection rate was 31.6% (37/117), and 30 years old (chi 2=4.544, P=0.033), 35~40 years (chi 2=8.857, P=0.003), 40~45 years (chi 2=11.976, P=0.001), 45~50 years (chi square) and 50 years of age (chi square), the difference was statistically significant. 37.6% (44/117), high risk HPV infection rate was 31.6% (37/117), the highest, and compared with other age groups, the difference was statistically significant, P0.05, consistent with the epidemiological characteristics. Liquid based cytology results showed that HPV infection was closely related to cervical intraepithelial lesion. Conclusion high risk type HPV16,58 and type 52 are the dominant type in Yichang region It should be included in the research focus of HPV vaccine..30~35 year old women should be included in the screening of cervical precancerous lesions or cervical cancer.
【作者单位】：三峡大学第一临床医学院;宜昌市中心人民医院体检中心;
【基金】：宜昌市科技局科研项目(A09301-10)
【分类号】：R737.33

【参考文献】