新生化片与米非司酮甲氨喋呤治疗异位妊娠的临床效果与安全性评价

发布时间：2018-06-15 09:52

本文选题：新生化片 + 米非司酮　；参考：《四川中医》2016年11期

【摘要】：目的:评价新生化片与米非司酮、甲氨喋呤三联治疗异位妊娠的临床效果与安全性,为异位妊娠临床治疗方案的制定与选择提供理论依据。方法:以我院2014年6月~2016年1月收治的82例异位妊娠患者为研究对象,根据用药方案分为研究组(n=24)和对照组(n=58),均给予甲氨蝶呤、米非司酮治疗,研究组加用新生化片治疗,持续7d。观察并比较两组患者治疗效果、β人绒毛膜促性腺激素(血β-HCG)水平变化及不良反应,评价两种治疗方案的临床效果及安全性。结果:研究组治疗成功率、治疗成功时间、包块缩小30%率均显著高于对照组,其住院时间显著低于后者,差异有统计学意义(P0.05)。两组患者治疗后血β-HCG均显著下降,研究组下降更为明显,且血β-HCG复常时间显著低于对照组,差异有统计学意义(P0.05)。研究组、对照组不良反应发生率分别为16.7%、19.0%,组间比较差异无统计学意义(P0.05)。结论:新生化片与米非司酮、甲氨蝶呤三联治疗方案能够在不增加不良反应发生率的前提下,有效提高异位妊娠的治疗成功率、缩短治疗时间,其确切的疗效及良好的安全性值得肯定,建议推广。
[Abstract]:Objective: to evaluate the efficacy and safety of neo-biochemistry tablets, mifepristone and methotrexate in the treatment of ectopic pregnancy. Methods: 82 patients with ectopic pregnancy admitted in our hospital from June 2014 to January 2016 were divided into two groups according to the drug regimen: the study group and the control group. All patients were treated with methotrexate and mifepristone, and the study group was treated with new biochemical tablets. Last 7 days. The therapeutic effect, serum 尾 -HCG level and adverse reactions were observed and compared between the two groups, and the clinical efficacy and safety of the two treatments were evaluated. Results: the success rate, successful time and 30% reduction rate of mass in the study group were significantly higher than those in the control group, and the hospitalization time was significantly lower than that in the control group (P 0.05). After treatment, the serum 尾 -HCG decreased significantly in both groups, especially in the study group, and the recovery time of serum 尾 -HCG was significantly lower than that of the control group (P 0.05). In the study group, the incidence of adverse reactions in the control group was 16.7% and 19.0 respectively, and there was no significant difference between the two groups (P 0.05). Conclusion: new biochemistry tablets, mifepristone and methotrexate can effectively improve the success rate and shorten the treatment time of ectopic pregnancy without increasing the incidence of adverse reactions. Its exact curative effect and good safety are worthy of affirmation, suggest popularizing.
【作者单位】：马鞍山市妇幼保健医院妇产科;
【分类号】：R714.22

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