H1受体拮抗剂异丙嗪降低紫杉醇对卵巢癌的化疗作用

发布时间：2018-06-15 17:06

本文选题：H受体 + 受体拮抗剂　；参考：《中国病理生理杂志》2015年10期

【摘要】：正目的:观察紫杉醇化疗时为缓解过敏反应而常规联用的组胺H1受体拮抗剂是否影响其疗效。方法:构建荷人卵巢癌裸鼠模型,随机分为对照、单用紫杉醇、单用异丙嗪、异丙嗪+紫杉醇4组,6.5 mg/kg异丙嗪或生理盐水腹腔注射给药0.5 h后,再予腹腔注射10 mg/kg紫杉醇或生理盐水(每3 d 1次,共4次),测量肿瘤体积和瘤重。免疫组化检测肿瘤血管标志物CD31
[Abstract]:Aim: to observe whether the combined histamine H 1 receptor antagonist, which is used in combination with paclitaxel to relieve allergic reaction, affects the efficacy of paclitaxel. Methods: the nude mice bearing human ovarian cancer were randomly divided into two groups: paclitaxel alone, promethazine alone and propofol group (4 groups) after intraperitoneal injection of promethazine or normal saline for 0.5 h. The tumor volume and tumor weight were measured by intraperitoneal injection of 10 mg/kg paclitaxel or normal saline (once every 3 days, 4 times). Detection of tumor vascular marker CD31 by immunohistochemistry
【作者单位】：第二军医大学病理生理学教研室;
【基金】：国家自然科学基金资助项目(No.81172471)
【分类号】：R737.31

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