精浆弹性硬蛋白酶水平对IVF-ET正常受精、优质胚胎的影响

发布时间：2018-06-16 16:57

本文选题：体外受精 + 精浆弹性硬蛋白酶　；参考：《山东医药》2017年05期

【摘要】：目的探讨精浆弹性硬蛋白酶对体外受精-胚胎移植(IVF-ET)正常受精、优质胚胎的影响。方法选择因女方输卵管因素行促性腺激素释放激素激动剂长方案卵巢控制性刺激的1 183对周期不孕夫妇。按照男性生殖系统感染情况将女性分为三组:未感染(精浆弹性硬蛋白酶水平290 ng/m L)组703例、隐性感染(精浆弹性硬蛋白酶水平290~1 000 ng/m L)组385例、确证感染(精浆弹性硬蛋白酶水平1 000 ng/m L)组95例。排除获卵数≤5个或≥20个、女方年龄≥35岁,三组经校正后未感染组159例、隐性感染组137例、感染组41例。均行IVFET,对比各组校正前后正常受精率、优质胚胎率。结果校正前三组正常受精率、优质胚胎率比较差异无统计学意义(P均0.05)。校正后三组正常受精率比较差异有统计学意义(P0.05),优质胚胎率比较差异无统计学意义(P0.05);与隐性感染组、未感染组比较,感染组正常受精率降低(P0.017)。结论排除女方高龄、卵巢低反应及卵巢高反应人群,卵巢正常储备女性其丈夫精浆弹性硬蛋白酶水平对IVF-ET正常受精率有影响,对优质胚胎率影响不大。
[Abstract]:Objective to investigate the effect of seminal plasma elastic hard proteinase on normal fertilization and high quality embryos in vitro fertilization and embryo transfer (IVF-ET). Methods 1183 couples with cyclical infertility due to the long scheme of gonadotropin releasing hormone agonists were selected because of female fallopian tube factors. Women were divided into three groups according to the male reproductive system infection. No infection (seminal plasma elastic hard proteinase level 290 ng/m L) group 703 cases, recessive infection (seminal elastic hard proteinase level 290~1 000 ng/m L) group 385 cases, confirmed infection (seminal plasma elastic hard proteinase level 1000 ng/m L) group 95 cases. Exclude the number of eggs less than 5 or more than 20, the female age is more than 35 years old, three groups after correction of the group 159 cases, hidden sexy group, implicit sex 137 cases and 41 cases of infection group were treated with IVFET. The normal fertilization rate and high quality embryo rate were compared before and after correction. The results of normal fertilization rate in the first three groups were corrected. The difference of high quality embryo rate was not statistically significant (P 0.05). The difference of normal fertilization rate in the three groups was statistically significant (P0.05), and there was no statistical difference between the high quality embryo rate and the rate of high quality embryos. P0.05; compared with the recessive infection group, the normal fertilization rate in the infected group was lower than that in the uninfected group (P0.017). Conclusion excluding the female age, the ovarian hyper reaction and the ovarian hyper response population, the normal ovarian reserve of the women whose husbands' seminal elastic hard protease levels have an influence on the normal fertilization rate of IVF-ET, and have little effect on the high quality embryo rate.
【作者单位】：山东中医药大学;山东中医药大学附属医院;山东省妇幼保健院;
【基金】：山东省重点研发计划项目(2015GSF119018)
【分类号】：R714.8

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