111例卵巢恶性生殖细胞肿瘤的临床特征及预后分析

发布时间：2018-06-17 17:01

本文选题：卵巢恶性生殖细胞肿瘤 + 外科手术　；参考：《现代妇产科进展》2017年05期

【摘要】：目的:探讨卵巢恶性生殖细胞肿瘤的临床特征与预后的关系,为临床研究和治疗提供参考依据。方法:回顾分析我院2003年1月至12月收治的111例卵巢恶性生殖细胞肿瘤的临床资料。分析患者的发病年龄、病理类型、手术病理分期、手术方式、肿瘤标记物高低、术后化疗疗程等因素对患者预后的影响及化疗对月经生育状况的影响。结果:本组患者中位发病年龄22岁,平均(21.43±12.92)岁。患者均行手术治疗。99例在初次手术中保留了生育功能,95例接受了术后补充化疗,1~8个疗程。平均随访时间78.0个月,失访3例。3年生存率98.1%(106/108),5年生存率94.7%(71/75)。不同病理分期、肿瘤类型的5年生存率比较,差异有统计学意义(P0.05);不同病理分期、化疗疗程的总生存率比较,差异有统计学意义(P0.05)。23例化疗前月经规律的患者于化疗第2~3个疗程开始出现月经异常现象,均于化疗结束3~5月恢复正常。31例患者成功自然妊娠并分娩,31例新生儿均体健。结论:卵巢恶性生殖细胞肿瘤患者的总生存率与手术-病理分期及化疗疗程有关,化疗对卵巢功能和生育无明显影响。
[Abstract]:Objective: to investigate the relationship between clinical features and prognosis of ovarian malignant germ cell tumor and to provide reference for clinical study and treatment. Methods: the clinical data of 111 cases of malignant germ cell tumor of ovary treated in our hospital from January to December 2003 were analyzed retrospectively. To analyze the influence of age, pathological type, stage, mode of operation, tumor marker, postoperative chemotherapy course on the prognosis of patients and the influence of chemotherapy on menstrual fertility. Results: the median age of onset was 22 years (mean 21.43 卤12.92) years. All the patients were treated with operation. 95 patients with reproductive function preserved during the first operation received 1 ~ 8 courses of postoperative supplementary chemotherapy. The average follow-up time was 78.0 months, 3 cases were lost, the 3-year survival rate was 98.1 / 106 / 108, and the 5-year survival rate was 94.771 / 75 / 75. The 5-year survival rate of different pathological stages and tumor types was significantly different (P 0.05), and the overall survival rate of different pathological stages and chemotherapy courses was higher than that of the control group. The difference was statistically significant in 23 patients with menstrual regularity before chemotherapy. The abnormal menstruation began to appear in the 2nd ~ 3rd course of chemotherapy, and all of them returned to normal from 3 to 5 months after chemotherapy. 31 cases of spontaneous pregnancy and 31 cases of newborn were healthy. Conclusion: the overall survival rate of patients with ovarian malignant germ cell tumor is related to the operative-pathological stage and the course of chemotherapy. There is no significant effect of chemotherapy on ovarian function and fertility.
【作者单位】：新疆医科大学附属肿瘤医院;重庆医科大学第一临床学院;
【分类号】：R737.31

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