中医药分步论治再次IVF-ET患者降调日至胚胎移植日助孕疗效分析

发布时间：2018-06-19 00:57

本文选题：中医药分步论治 + 肾虚肝郁血瘀　；参考：《时珍国医国药》2017年11期

【摘要】：目的客观分析中医药分步论治IVF-ET失败患者再次IVF-ET降调日至胚胎移植日助孕疗效。方法选取符合纳入标准的137例四川大学华西第二医院生殖中心行IVF-ET长方案失败后的患者(肾虚肝郁血瘀型)为对象,采用随机分组(治疗组72例;对照组65例),观察两组治疗后再次IVF-ET降调日至胚胎移植日助孕周期的获成熟卵子数、受精卵数、受精率、获新鲜胚胎数、HCG日及ET日子宫内膜厚度、周期取消率、起始周期移植率、取卵周期移植率等情况。结果(1)中医药分步论治可改善IVF-ET患者的HCG日内膜厚度、ET日内膜厚度;提高获受精卵数、受精率及获新鲜胚胎数。治疗前后比较:对照组差异无统计学意义(P0.05);治疗组差异有统计学意义(P0.05),疗后优于疗前。疗后两组组间比较,差异有统计学意义(P0.05),治疗组优于对照组。(2)中医药分步论治可提高IVF-ET患者的起始、取卵周期移植率,降低周期取消率。治疗前后比较:治疗组差异均有统计学意义(P0.05),疗后优于疗前;对照组差异无统计学意义(P0.05)。疗后两组组间比较:采用χ2检验,差异均无统计学意义(P0.05)。结论中医药分步论治可改善IVF-ET患者的HCG日内膜厚度、ET日内膜厚度;提高获受精卵数、受精率及获新鲜胚胎数;提高IVF-ET患者的起始、取卵周期移植率,降低周期取消率。
[Abstract]:Objective to analyze the therapeutic effect of IVF-ET on IVF-et failure from the day of lowering IVF-et to the day of embryo transfer. Methods 137 patients (kidney deficiency, liver stagnation and blood stasis) were selected from reproductive center of West China Hospital of Sichuan University after the failure of IVF-ET. The patients were randomly divided into two groups (treatment group, 72 cases). The number of mature eggs, fertilized eggs, fertilization rate, endometrial thickness on HCG day and et day, and the rate of cycle cancellation were observed in the control group (65 cases) from the second IVF-ET down-modulation day to the embryo transfer day, the number of fertilized eggs, the thickness of endometrium on the day of HCG and et, and the rate of cycle cancellation. The rate of initial cycle transplantation and oocyte cycle transplantation. Results 1) Chinese medicine can improve the thickness of HCG and et, increase the number of fertilized eggs, fertilization rate and the number of fresh embryos in IVF-ET patients. Comparison before and after treatment: there was no significant difference between control group (P 0.05) and treatment group (P 0.05), which was better than that before treatment. There was significant difference between the two groups after treatment. The treatment group was superior to the control group (P < 0.05). The treatment group was better than the control group. The step by step treatment with Chinese medicine could improve the initiation rate of IVF-ET patients, the transplant rate of oocyte collection cycle and the rate of cycle cancellation. Comparison before and after treatment: the difference between the treatment group and the control group was statistically significant (P 0.05), which was better than that before treatment, while in the control group there was no significant difference (P 0.05). After treatment, there was no significant difference between the two groups by 蠂 2 test (P 0.05). Conclusion Chinese medicine can improve the thickness of HCG and et in IVF-ET patients, increase the number of fertilized eggs, fertilization rate and the number of fresh embryos, increase the initiation of IVF-ET patients, the rate of oocyte cycle transplantation, and reduce the rate of cycle cancellation.
【作者单位】：成都中医药大学附属医院;四川大学华西第二医院;重庆市中医院;成都西囡妇科医院;成都中医药大学临床医学院;
【基金】：四川省科技厅科研项目(2016SZ0037) 四川省中医药管理局科研项目(2016C022)
【分类号】：R714.8

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