妊娠期妇女B族链球菌感染对母儿预后影响的研究

发布时间：2018-06-20 03:43

本文选题：孕妇 + B族链球菌　；参考：《中国实用妇科与产科杂志》2017年08期

【摘要】：目的探讨妊娠期妇女B族链球菌(GBS)感染对新生儿危害及母儿预后的影响。方法选取2014年6月至2016年7月曲靖市第一人民医院产科门诊接受产检的35~37周3000例待产孕妇阴道和直肠分泌物及分娩后新生儿的脐带血。分别采用实时荧光定量PCR(QF-PCR)法和细菌培养法对分泌物及新生儿脐带血进行GBS检测。分析GBS感染对围产期母儿预后的影响。结果 GBS在阴道及直肠的总定植率为10.3%,阴道和直肠GBS定植率分别为9.23%、10.13%,检出率分别为89.6%、98.4%,差异无统计学意义(P0.05)。GBS对青霉素类、头孢吡肟、万古霉素和氨苄西林的敏感度为100%。GBS阳性组与GBS阴性组在母儿结局如早产、剖宫产、胎膜早破、霉菌性阴道炎、宫内感染、胎儿窘迫、新生儿窒息、新生儿肺炎的发生率比较差异有统计学意义(χ2值分别为13.904、4.868、8.382、39.799、46.570、43.624、40.429、91.571,P0.05)。结论妊娠期妇女GBS感染可能会对母儿预后造成不良影响,临床上有必要进行常规GBS检测,并对GBS阳性菌株进行药敏试验,以便有效的进行干预治疗,以保证围产期母儿的健康。
[Abstract]:Objective to investigate the effects of group B streptococcus B (GBS) infection on neonatal hazards and maternal and fetal prognosis in pregnant women. Methods from June 2014 to July 2016, 3000 expectant pregnant women with vaginal and rectal secretions and umbilical cord blood were collected from the obstetrical outpatient clinic of the first people's Hospital of Qujing City from June 2014 to July 2016. The secretion and umbilical cord blood of newborn were detected by real-time fluorescence quantitative PCRF-PCRand bacterial culture. To analyze the effect of GBS infection on perinatal maternal and fetal prognosis. Results the total colonization rate of GBS in vagina and rectum was 10.3, and the colonization rate of GBS in vagina and rectum was 9.23 and 10.13.The positive rate was 89.6and 98.4, respectively. There was no significant difference in penicillin and cefepime between GBS and GBS. The sensitivity of vancomycin and ampicillin was 100. GBS positive group and GBS negative group in maternal and fetal outcomes such as premature delivery, cesarean section, premature rupture of membranes, fungal vaginitis, intrauterine infection, fetal distress, neonatal asphyxia, There was significant difference in the incidence of neonatal pneumonia (蠂 ~ 2 = 13.9044.868 / 8.382U 46.570g / 43.624 / 40.429 / 91.571/ P 0.05 respectively). Conclusion GBS infection in pregnant women may have adverse effects on the prognosis of mother and fetus. It is necessary to carry out routine GBS detection and drug sensitivity test for GBS positive strains in order to effectively intervene and to ensure the health of perinatal mothers and infants.
【作者单位】：曲靖市第一人民医院产科;
【分类号】：R714.251

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