黄体酮注射液与阴道缓释凝胶对实施体外受精与胚胎移植技术孕妇妊娠结局的影响比较:Meta分析

发布时间：2018-06-20 15:19

本文选题：受体 + 孕酮　；参考：《福建医科大学学报》2017年01期

【摘要】：目的比较黄体酮2种剂型(阴道缓释凝胶与注射液)对实施基于非冻融胚胎的体外受精与胚胎移植技术(IVF-ET)孕妇的妊娠结局的影响。方法计算机检索Cochrane Library、Embase、PubMed、Elsevier、ResearchGate、万方医学数据库、中国知网数据库、维普全文数据库,搜集关于黄体酮阴道缓释凝胶与黄体酮注射液影响IVF-ET结局的随机对照试验研究。采用Revman5.3版软件对数据进行Meta分析。结果共纳入10项研究。所有纳入研究的患者分为阴道缓释凝胶组和肌内注射组。Meta分析结果显示,2组的临床妊娠率(RR=0.98,95%CI:0.90~1.07)、继续妊娠率(RR=0.96,95%CI:0.79~1.17)、流产率(RR=0.80,95%CI:0.59~1.10)、活产率(RR=1.13,95%CI:0.97~1.31)无统计学差别。结论黄体酮阴道缓释凝胶和肌内注射液对采用IVF-ET妊娠结局相同。
[Abstract]:Objective to compare the effects of two dosage forms of progesterone (vaginal sustained-release gel and injection) on pregnancy outcome of pregnant women undergoing IVF-ET-based IVF-ET-based fertilization and embryo transfer with non-freeze-thawed embryos. Methods A randomized controlled trial was conducted to search for the effects of progesterone vaginal sustained-release gel and progesterone injection on the outcome of IVF-ET by searching the Cochrane Library Embase Meden Elsevier Research Medicine Database, China knowledge Web Database and Wiper Full-text Database on the effect of progesterone vaginal sustained release gel and progesterone injection on the outcome of IVF-ET. The data were analyzed with Revman 5.3 software. Results A total of 10 studies were included. All the patients included in the study were divided into vaginal sustained-release gel group and intramuscular injection group. Meta-analysis results showed that there was no significant difference in the clinical pregnancy rate of RRN 0.98 ~ 95CI: 0.90: 1.07m, the continuing pregnancy rate and the RRR0.7995% 1.17%, the abortion rate RR0.8095CI0.591.10 and the live birth rate RRR1.1395CI0.97CI0.97c1.31). Conclusion progesterone vaginal sustained release gel and intramuscular injection have the same pregnancy outcome with IVF-et.
【作者单位】：厦门大学附属第一医院妇产科;厦门大学附属第一医院计算机中心;
【分类号】：R714.8

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