接受高效价联合抗反转录病毒治疗的HIV感染孕妇营养状态与不良出生结局的关系

发布时间：2018-06-21 19:34

本文选题：高效价联合抗反转录病毒治疗 + 孕期增重　；参考：《广东医学》2017年22期

【摘要】：目的研究接受高效价联合抗反转录病毒疗法(HAART)治疗的艾滋病病毒(HIV)感染孕妇的营养状况与不良出生结局之间的关系。方法通过对接受正规治疗并定期产检的HIV感染孕妇跟踪研究首次产检和孕期体重及体质指数、孕期增重、新生儿出生体重、身长等多项指标,描述接受HAART治疗的HIV感染孕妇的基础营养状况,分析孕妇的营养状况和不良出生结局之间的关系。结果共有55例孕妇完成调查随访,孕妇孕期体重增加2~20 kg,平均增重(10.35±3.98)kg。分娩孕周31~39+6周,新生儿体重1.8~3.95 kg,平均(2.8±0.47)kg,新生儿评分8~10分,无窒息儿出生。出生低体重儿12例(21.8%),胎儿生长受限7例(12.7%),早产7例(12.7%)。孕期增重不足组33例,占60%,其新生儿体重、身长、头围值显著低于孕期增重正常组,差异有统计学意义(P0.05,P0.01),且低出生体重发生率显著高于孕期增重正常组(P0.05)。Pearson简单相关分析表明,孕期增重与新生儿体重呈显著正相关(r=0.549,P0.01)。结论接受HAART治疗的HIV感染孕妇营养状况一般,孕期体重增加明显不足,出生低体重儿发生率高,孕期增重不足与新生儿出生低体重相关。
[Abstract]:Objective to study the relationship between nutritional status and adverse birth outcomes of HIV-infected pregnant women treated with high titer combined with antiretroviral therapy (HAART). Methods the pregnant women with HIV infection who received regular treatment and regular birth examination were followed up to study such indexes as body weight and body mass index, weight gain during pregnancy, birth weight of newborn, length of body, etc. The basic nutritional status of HIV-infected pregnant women treated with HAART was described and the relationship between nutritional status and poor birth outcome was analyzed. Results A total of 55 pregnant women were followed up. The pregnant women gained 20 kg weight and 10.35 卤3.98 kg weight gain during pregnancy. The newborn weight was 1.8 卤3.95 kg (mean 2.8 卤0.47 kg), the neonatal score was 810 ~ 10, and the unasphyxiated infant was born. There were 12 cases of low birth weight infants, 7 cases of fetal growth restriction, 7 cases of premature birth and 7 cases of premature birth. There were 33 cases (60%) with insufficient weight gain during pregnancy. The neonatal weight, body length and head circumference value were significantly lower than those of normal weight gain group during pregnancy. The difference was statistically significant (P 0.05), and the incidence of low birth weight was significantly higher than that of normal weight gain group during pregnancy (P 0.05N. Pearson). There was a significant positive correlation between weight gain during pregnancy and neonatal body weight. Conclusion the nutritional status of HIV-infected pregnant women treated with HAART is general, the weight gain during pregnancy is obviously insufficient, the incidence of low birth weight infants is high, and the insufficient weight gain during pregnancy is related to the low birth weight of newborns.
【作者单位】：广州市第八人民医院妇产科;广州市第八人民医院感染科;
【基金】：广东省科技计划项目(编号:2013B021800053)
【分类号】：R714.251

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