宫颈癌IMAT与IMRT疗效比较研究

发布时间：2018-06-23 02:45

本文选题：宫颈肿瘤/放射疗法 + 旋转调强放疗　；参考：《医学与哲学(B)》2015年10期

【摘要】：通过比较宫颈癌静态调强放疗(IMRT)与旋转调强放疗(IMAT)计划,分析在瓦里安Clinical 23IX加速器实施IMAT技术治疗宫颈癌的优缺点。选取18例在本院Clinical 23IX加速器进行IMRT治疗的宫颈癌术后患者重新设计IMAT计划。使用Oncentra 4.1计划系统,模拟处方剂量为50.4Gy分28次。通过剂量体积直方图(dose volume histograms,DVH)统计PTV,CTV和外危及器官(organs at risk,OAR)剂量体积参数以及治疗机器跳数(MU)和治疗时间。用SPSS 19.0软件对2个组数据进行配对T检验分析。显示IMAT计划组PTV的适形指数(CI),CTV的均匀指数(HI)、CI、D90、D95、D98、V95、V98、V100,脊髓D2和直肠V40以及治疗时间和治疗MU均优于IMRT组。IMRT计划组在降低膀胱V50,小肠V30以及低剂量受照区域要优于IMAT组。在瓦里安Clinical 23IX加速器设计的宫颈癌患者IMAT计划可以达到与IMRT相似或更好的剂量学分布,治疗时间短,MU少,可减少治疗中不确定性因素影响及患者不适感。
[Abstract]:By comparing static intensity modulated radiotherapy (IMRT) and rotational intensity modulated radiotherapy (IMAT) for cervical cancer, the advantages and disadvantages of IMAT in Varian Clinical 23IX accelerator were analyzed. The IMAT plan was redesigned in 18 patients with cervical cancer treated with IMRT at Clinical 23IX accelerator in our hospital. Using Oncentra 4.1 planning system, the simulated prescription dose was 50.4 Gy fraction 28 times. Dose volume parameters, therapeutic machine hops (MU) and time of treatment were calculated by dose volume histogram (dose volume) histogram. Two groups of data were analyzed by paired T test with SPSS 19.0 software. The results showed that the conformal index (CI) and uniform index (HI) of CTV in IMAT planning group were better than those in IMRT group in decreasing bladder V50, small intestine V30 and low dose exposure area. The spinal cord D2 and rectum V40, the treatment time and the treatment MU were superior to those in IMAT group. The IMAT program of cervical cancer patients designed at Varian Clinical 23IX accelerator can achieve dose distribution similar to or better than IMRT. The treatment time is short and MU is less, which can reduce the influence of uncertain factors and the discomfort of patients.
【作者单位】：河北医科大学第四医院放射治疗科;河北医科大学第四医院妇瘤科;
【分类号】：R737.33

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