生长分化因子15蛋白在宫颈上皮内瘤变和鳞癌中的表达及意义

发布时间：2018-06-23 10:29

本文选题：子宫颈肿瘤 + 鳞状细胞癌　；参考：《实用医学杂志》2015年02期

【摘要】：目的:探讨生长分化因子-15(growth differentiation factor-15,GDF-15)蛋白在宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)和鳞癌中的表达及其在宫颈鳞癌发生和发展中的意义。方法 :采用免疫组织化学法分别检测45例宫颈癌(宫颈癌组),90例CIN(CIN1、CIN2、CIN3各30例),30例正常宫颈组织(对照组)的GDF-15的表达情况。结果 :GDF-15在对照组、CIN组、宫颈癌组的阳性率分别为10.0%(3/30)、45.6%(41/90)和80.0%(36/45),CIN组中,阳性率CIN1组为26.7%(8/30),CIN2组为53.3%(16/30),CIN3组为56.7%(17/30)。统计发现GDF-15在CIN组中阳性表达率明显高于对照组中的表达(Z=870.0,P=0.000),CIN2和CIN3的阳性表达率均明显高于CIN1(分别Z=330.0,P=0.037;Z=315.0,P=0.019),宫颈癌组中的阳性率明显高于CIN3组(Z=-2.16,P=0.031)。结论:GDF-15蛋白在正常宫颈组织、CIN、宫颈鳞癌中随着宫颈病变的进展其阳性表达率呈明显上升趋势,检测GDF-15表达可能有助于预测宫颈高度病变的转归。
[Abstract]:Objective: to investigate the expression of growth differentiation factor-15 (GDF-15) protein in cervical intraepithelial neoplasia (cervical intraepithelial neoplasia cin) and squamous cell carcinoma (SCC) and its significance in the occurrence and development of cervical squamous cell carcinoma (SCC). Methods: the expression of GDF-15 in 45 cases of cervical carcinoma (cervical carcinoma group) and 90 cases of cin (30 cases of cin 1 CIN2CIN3) and 30 cases of normal cervical tissue (control group) were detected by immunohistochemical method. Results in the control group, the positive rates were 10.0% (3 / 30), 45.6% (41 / 90) and 80.0% (36 / 45), respectively. The positive rate of CIN1 group was 26.7% (830 / 830), and the positive rate of CIN2 group was 53.3% (16 / 30) CIN3 group was 56.7% (17 / 30). The positive expression rate of GDF-15 in cin group was significantly higher than that in control group (Zn870.0P0. 000), CIN2 and CIN3 expression rates were significantly higher than that in CIN1 group (Zn3333. 0. 037, Zn315.0 Pn0. 019), and the positive rate of GDF-15 in cervical cancer group was significantly higher than that in CIN3 group (Zn2. 16P0. 031). The positive rate of GDF-15 in cin group was significantly higher than that in CIN3 group (ZN3 group), and the positive rate of CIN3 group was significantly higher than that of CIN3 group. Conclusion the positive expression rate of VGDF-15 protein in normal cervical tissue and cervical squamous cell carcinoma is obviously increasing with the development of cervical lesions. The detection of GDF-15 expression may be helpful to predict the outcome of cervical hyperpathic lesions.
【作者单位】：广东省增城市人民医院(中山大学附属博济医院)妇科;广东省增城市人民医院(中山大学附属博济医院)病理科;中山大学孙逸仙纪念医院妇科;
【分类号】：R737.33

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