亚临床甲减对早孕期反复妊娠丢失女性的影响

发布时间：2018-06-23 11:47

本文选题：亚临床甲状腺功能减退 + 反复妊娠丢失　；参考：《中国妇产科临床杂志》2015年05期

【摘要】：目的探讨亚临床甲状腺功能减退(subclinical hypothyroidism,SCH)对早孕期反复妊娠丢失(recurrent early pregnancy loss,REPL)女性的影响。方法以346例早孕期反复妊娠丢失的女性为研究对象,对2009年8月至2011年11月的25例SCH患者未予治疗,对2011年12月至2013年11月的21例SCH患者孕前均予口服左旋甲状腺素,通过观察性队列研究,比较两组人群活产率的差异。结果 SCH的患者在REPL人群的发病率为18.5%;46例SCH患者累积妊娠84次,其中活产32例,活产率为38.1%,210例甲功正常患者累积妊娠361次,其中活产150例,活产率为41.6%,两组活产率差异无统计学意义(P0.05);接受左旋甲状腺素药物治疗的21例SCH患者活产率为58.0%,未接受左旋甲状腺素药物治疗的25例SCH患者活产率为26.0%,两组活产率差异有统计学意义(P0.05)。结论 SCH在RELP人群中有较高的发病率,口服左旋甲状腺素可提高SCH患者的活产率。
[Abstract]:Objective to investigate the effect of subclinical hypothyroidism (subclinical hypothyroidism Sch) on women with recurrent pregnancy loss of (recurrent early pregnancy in early pregnancy. Methods 346 women with recurrent pregnancy loss during early pregnancy were studied. 25 patients with Sch from August 2009 to November 2011 were treated untreated, and 21 patients with Sch from December 2011 to November 2013 were treated with levothyroxine before pregnancy. A cohort study was conducted to compare the difference of live birth rate between the two groups. Results the incidence rate of Sch in REPL patients was 84 times, including 32 live births, 38.1% of 210 cases of normal thyroid function, and 150 cases of live births, among which there were 150 cases of live births, while the incidence of 18. 5% of the total pregnancy was 18. 5% in 46 patients with Sch, including 32 cases of live labor, and 210 cases of normal thyroid function. The live birth rate of the two groups was 41.6, there was no significant difference between the two groups (P0.05), the live birth rate of 21 patients with Sch treated with levothyroxine was 58.0, and that of 25 patients without levothyroxine was 26.0. The difference was statistically significant (P0.05). Conclusion there is a high incidence of Sch in RELP population, and oral administration of levothyroxine can improve the live delivery rate of patients with Sch.
【作者单位】：北京积水潭医院妇产科;卫生部中日医院妇产科;
【分类号】：R581.2;R714.21

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