子宫内膜癌组织中长链非编码RNA ANRIL的表达变化及其意义

发布时间：2018-06-25 00:16

  本文选题：子宫肿瘤 + 子宫内膜癌　； 参考：《山东医药》2017年19期

【摘要】：目的观察子宫内膜癌组织中长链非编码RNA(lncRNA)ANRIL的表达变化,并探讨其临床意义。方法子宫内膜癌患者40例(观察组),均行子宫切除术,术中留取子宫内膜癌组织;另选择因阴道异常出血行宫腔镜刮宫活检或因子宫肌瘤行全子宫切除术的患者40例(对照组),术中留取正常子宫内膜组织标本。采用实时荧光定量PCR法检测两组组织ANRIL,分析ANRIL表达与子宫内膜癌临床病理参数的关系。结果观察组、对照组组织中ANRIL的相对表达量分别为19.89(5.26,61.42)和6.08(1.62,27.79),两者相比,P0.05。观察组病理分级为Ⅰ+Ⅱ级、Ⅲ级组织中ANRIL的相对表达量分别为6.12(1.58,24.65)、15.21(6.12,59.73),两者相比,P0.05。ANRIL表达与子宫内膜癌患者年龄、FIGO病理分期及有无盆腔淋巴结转移、是否合并高血压、糖尿病、雌激素及孕激素水平均无关(P均0.05)。结论子宫内膜癌组织中ANRIL表达升高,ANRIL可能参与了子宫内膜癌的发生、发展。
[Abstract]:Objective to investigate the changes of ANRIL expression in endometrial carcinoma and its clinical significance. Methods 40 cases of endometrial carcinoma (observation group) were treated with hysterectomy. Another 40 patients (control group) who underwent hysteroscopic curettage biopsy or hysteromyoma hysterectomy due to abnormal vaginal bleeding were selected. The relationship between ANRIL expression and clinicopathologic parameters of endometrial carcinoma was analyzed by real-time fluorescent quantitative PCR. Results the relative expression levels of ANRIL in the observation group and control group were 19.89 (5.2651.42) and 6.08 (1.62P 27.79), respectively. In the observation group, the relative expression of ANRIL was 6.12 (1.5824.65) and 15.21 (6.1259.73) respectively. The expression of ANRIL was higher than that of P0.05. ANRIL expression and Figo pathological stage and pelvic lymph node metastasis in patients with endometrial carcinoma. The levels of estrogen and progesterone were not significant (P 0.05). Conclusion the increased expression of ANRIL in endometrial carcinoma may be involved in the occurrence and development of endometrial carcinoma.
【作者单位】： 河北医科大学第一医院;
【基金】：河北省自然科学基金资助项目(H2012206040)
【分类号】：R737.33
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本文编号：2063630