来曲唑用于多囊卵巢综合征患者促排卵的临床疗效及安全性评价

发布时间：2018-06-25 03:30

本文选题：多囊卵巢综合征 + 来曲唑　；参考：《中国临床药理学杂志》2015年19期

【摘要】：目的评价不同剂量来曲唑用于多囊卵巢综合征患者促排卵的临床疗效和安全性。方法将88例拟进行促排卵治疗的多囊卵巢综合征患者随机分为对照组42例和试验组46例。2组患者均于月经来潮第3天起开始服药,对照组予以口服来曲唑2.5 mg·d-1,连续5 d;试验组予以口服来曲唑5 mg·d-1,连续5 d。月经周期第10天,开始进行阴道超声检查,并监测卵泡发育情况,比较2组患者的排卵率和周期妊娠率以及不良反应发生率。结果对照组有33例排卵,排卵率78.57%,临床妊娠2例,周期妊娠率为6.1%(2/33),试验组有34例排卵,排卵率为73.91%,临床妊娠9例,周期妊娠率为26.5%(9/34),其中试验组周期妊娠率显著高于对照组(P0.05)。对照组与试验组成熟卵泡数分别为(1.0±0.4)个和(1.5±0.6)个,试验组显著高于对照组(P0.05)。对照组用药期间发生关节痛2例、恶心1例,试验组发生关节痛1例、恶心1例,2组患者不良反应发生率比较差异无统计学意义(P0.05)。结论 5.0 mg·d-1来曲唑与2.5 mg·d-1来曲唑相比可显著提高多囊卵巢综合征患者的周期妊娠率,同时不增加不良反应风险。
[Abstract]:Objective to evaluate the efficacy and safety of different doses of letrozole in ovulation promotion in patients with polycystic ovary syndrome (PCOS). Methods Eighty-eight patients with polycystic ovary syndrome (PCOS) were randomly divided into control group (n = 42) and experimental group (n = 46). The control group was given oral letrozole 2.5 mg 路d ~ (-1) for 5 days, while the test group was given oral letrozole 5 mg 路d ~ (-1) for 5 days. On the 10th day of menstrual cycle, vaginal ultrasound was performed and follicle development was monitored. The ovulation rate, pregnancy rate and adverse reaction rate were compared between the two groups. Results there were 33 cases of ovulation in the control group (78.57%), 2 cases of clinical pregnancy, the rate of periodic pregnancy was 6.1% (2 / 33). In the test group, 34 cases were ovulated, the ovulation rate was 73.91, and the clinical pregnancy rate was 26.5% (934%). The pregnancy rate of the trial group was significantly higher than that of the control group (P0.05). The number of mature follicles in the control group and the experimental group were (1.0 卤0.4) and (1.5 卤0.6), respectively, which were significantly higher than those in the control group (P0.05). In the control group, there were 2 cases of joint pain, 1 case of nausea, 1 case of joint pain and 1 case of nausea. There was no significant difference in the incidence of adverse reactions between the two groups (P0.05). Conclusion compared with 2.5 mg d -1 letrozole, 5.0 mg d -1 letrozole can significantly increase the pregnancy rate of patients with polycystic ovary syndrome without increasing the risk of adverse reactions.
【作者单位】：福建医科大学附属第一医院妇产科;
【基金】：福建省卫生厅青年基金资助项目(0013023)
【分类号】：R711.75

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