n-3多不饱和脂肪酸对妊娠糖尿病患者胰岛素抵抗与妊娠结局影响的Meta分析

发布时间：2018-06-25 13:46

  本文选题：n-多不饱和脂肪酸 + 妊娠糖尿病　； 参考：《中华生殖与避孕杂志》2017年11期

【摘要】：目的系统评价n-3多不饱和脂肪酸对妊娠糖尿病患者胰岛功能、血脂代谢和妊娠结局的影响。方法检索英文数据库Medline、EMbase、Cochrane对照试验中心注册数据库(Cochrance Central register of controlled trials,CENTRAL),检索语言为英语,检索起止时间为2000年1月—2017年3月。检索词为gestational diabetes,n-3 polyunsaturated fatty acid,clinical trial。中文数据库为中国知网,检索起止时间为2000年1月—2017年3月,检索词为妊娠糖尿病、n-3多不饱和脂肪酸、临床研究。纳入对妊娠糖尿病患者添加n-3多不饱和脂肪酸的随机对照试验,采用Jadad量表进行研究质量评价,使用Rev Man5.2软件进行Meta分析。结果最终纳入5篇英文文献,来源于2个不同国家的高质量研究。n-3组的胰岛素释放(I~2=92%,95%CI=-4.95~-1.03,Z=2.99,P=0.003),新生儿高胆红素血症的发病率(I~2=0%,95%CI=0.07~0.58,Z=2.94,P=0.003),n-3组新生儿住院率低于对照组(I~2=0%,95%CI=0.07~0.64,Z=2.78,P=0.005),n-3组的血清总胆固醇高于对照组(I~2=82%,95%CI=2.39~10.61,Z=3.1,P=0.002),差异均有统计学意义。空腹血糖(FPG)(I~2=100%,95%CI=-9.87~16.98,Z=0.52,P=0.6)、血清甘油三酯(I~2=99%,95%CI=-40.69~20.85,Z=0.63,P=0.53)、需要接受胰岛素治疗的比例(I~2=0%,95%CI=0.05~2.16,Z=1.16,P=0.25)和巨大儿比例(I~2=9%,95%CI=0.11~1.45,Z=1.38,P=0.17)组间差异均无统计学意义。结论现有临床证据不足以证明n-3脂肪酸对改善妊娠糖尿病患者胰岛素抵抗和母代妊娠结局有益,但对新生儿健康状况有益作用。
[Abstract]:Objective to evaluate the effects of n-3 polyunsaturated fatty acids on islet function, lipid metabolism and pregnancy outcome in patients with gestational diabetes mellitus. Methods the English database Medlinea was retrieved from January 2000 to March 2017 in English as the search language for the Cochrance Central register of controlled trialscentral. The key word is gestational diabetes n-3 polyunsaturated fatty acidical trial. The Chinese database is Chinese information network. The search time is from January 2000 to March 2017. The key term is gestational diabetes mellitus (PDM) and polyunsaturated fatty acid (PUFA). A randomized controlled trial of adding n-3 polyunsaturated fatty acids to gestational diabetes mellitus patients was conducted. Jadad scale was used to evaluate the quality of the study, and Rev Man5.2 software was used for meta-analysis. The results were included in 5 English articles. 鏉ユ簮浜，

本文编号：2066176